Toward steadfast growth of antibiotic research in China: from natural products to engineered biosynthesis.
Toward steadfast growth of antibiotic research in China: from natural products to engineered biosynthesis.
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DOI：
10.1016/j.biotechadv.2011.09.001
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发表时间：
2012-11
影响因子：
16
通讯作者：
Q. Kang;Linquan Bai;Z. Deng
中科院分区：
文献类型：
--
作者：
Q. Kang;Linquan Bai;Z. Deng
抗生素在农业中被广泛用于临床治疗和防治疾病。克隆和研究它们的生物合成基因簇对于提高产量和设计具有新的和突出活性的新的衍生物是至关重要的。近年来，中国在这方面的研究异常活跃。本文综述了28种抗生素的生物合成进展，包括聚酮、非核糖体肽、聚酮-非核糖体肽杂化、多肽核苷、核苷等。揭示了它们的生物合成机理，并通过基因失活、突变合成和组合生物合成获得了具有新结构/活性的衍生物。
Antibiotics are widely used for clinical treatment and preventing or curing diseases in agriculture. Cloning and studies of their biosynthetic gene clusters are vital for yield enhancement and engineering new derivatives with new and prominent activities. In recent years, research in this aspect is impressively active in China. This article reviews biosynthetic progress on 28 antibiotics, including polyketides, nonribosomal peptides, hybrid polyketide–nonribosomal peptides, peptidyl nucleoside, nucleoside, and others. Their biosynthetic mechanisms were disclosed, and their derivatives with new structures/activities were obtained by gene inactivation, mutasynthesis and combinatorial biosynthesis.