Source localization of high-frequency activity in tripolar electroencephalography of patients with epilepsy
Source localization of high-frequency activity in tripolar electroencephalography of patients with epilepsy
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DOI：
10.1016/j.yebeh.2019.106519
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发表时间：
2019-12-01
影响因子：
2.6
通讯作者：
Besio, Walter G.
中科院分区：
文献类型：
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作者：
Toole, Christopher;Martinez-Juarez, Iris E.;Besio, Walter G.
目的：本研究的目的是本地化的发作间期高频活动（HFA）的来源，从三极脑电图（tEEG），在患者特定的，现实的头models.Methods：并发脑电图（EEG）和tEEG记录从9例患者接受视频脑电图，其中8个有癫痫发作期间的记录和其他癫痫活动。根据患者的磁共振图像（MRI）生成患者特定的、逼真的边界元素头部模型。结果：在本研究中，对9名癫痫患者进行了tEEG，观察到的HFA定位于受试者特定的、真实的皮层模型的表面，并且发现几乎完全发生在癫痫发作区（SOZ）/刺激区（IZ）。高频振荡（HFO）已被研究为癫痫SOZ的精确生物标志物，并在手术候选人中产生良好的治疗效果。了解这些高度聚焦事件的来源位于大脑中的何处可以帮助诊断。高频振荡在非侵入性EEG记录中不常见，通常需要侵入性皮层电图（ECoG）来检测它们。然而，tEEG，即，已经发现用三极同心环电极（TCREs）在头皮上记录的EEG检测与SOZ诊断相关的从高伽马（约80 Hz）到几乎400 Hz的窄带HFA。因此，tEEG中HFA的源定位可以帮助临床医生识别癫痫区的脑区域。至少，tEEG HFA定位可以帮助确定在何处进行用于精确诊断的颅内记录。(C)2019爱思唯尔公司All rights reserved.
Objective: The objective of the study was to localize sources of interictal high-frequency activity (HFA), from tripolar electroencephalography (tEEG), in patient-specific, realistic head models.Methods: Concurrent electroencephalogram (EEG) and tEEG were recorded from nine patients undergoing video-EEG, of which eight had seizures during the recordings and the other had epileptic activity. Patient-specific, realistic boundary element head models were generated from the patient's magnetic resonance images (MRIs). Forward and inverse modeling was performed to localize the HFA to cortical surfaces.Results: In the present study, performed on nine patients with epilepsy, HFA observed in the tEEG was localized to the surface of subject-specific, realistic, cortical models, and found to occur almost exclusively in the seizure onset zone (SOZ)/irritative zone (IZ).Significance: High-frequency oscillations (HFOs) have been studied as precise biomarkers of the SOZ in epilepsy and have resulted in good therapeutic effect in surgical candidates. Knowing where the sources of these highly focal events arc located in the brain can help with diagnosis. High-frequency oscillations are not commonly observed in noninvasive EEG recordings, and invasive electrocorticography (ECoG) is usually required to detect them. However, tEEG, i.e., EEG recorded on the scalp with tripolar concentric ring electrodes (TCREs), has been found to detect narrowband HFA from high gamma (approximately 80 Hz) to almost 400 Hz that correlates with SOZ diagnosis. Thus, source localization of HFA in tEEG may help clinicians identify brain regions of the epileptic zone. At the least, the tEEG HFA localization may help determine where to perform intracranial recordings used for precise diagnosis. (C) 2019 Elsevier Inc. All rights reserved.