Recent advances in understanding necrotizing enterocolitis.
Recent advances in understanding necrotizing enterocolitis.
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DOI：
10.12688/f1000research.17228.1
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Pierro, Agostino
中科院分区：
文献类型：
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作者：
Alganabi, Mashriq;Lee, Carol;Pierro, Agostino
坏死性小肠结肠炎是一种影响早产儿的破坏性肠道疾病。尽管新生儿护理方面的研究不断取得进展，但死亡率仍然很高，尤其是患有晚期疾病的婴儿。疾病发展的机制、肠道损伤的进展和治疗仍然是正在进行的研究和争议的领域。在这篇综述中，我们检查了我们目前对该疾病、其流行病学、与该疾病发生相关的危险因素及其病理生理学的了解。我们还描述了当前的管理和新兴研究，强调了未来潜在的方向。
Necrotizing enterocolitis is a devastating intestinal disease affecting preterm infants. In spite of ongoing research and advancement in neonatal care, mortality remains high, especially in infants with advanced disease. The mechanism of disease development, the progression of intestinal injury, and management remain areas of ongoing research and controversy. In this review, we examine our current understanding of the disease, its epidemiology, the risk factors associated with the development of the disease, and its pathophysiology. We also describe current management and new emerging research highlighting potential future directions.