Positioning SUMO as an immunological facilitator of oncolytic viruses for high-grade glioma.
Positioning SUMO as an immunological facilitator of oncolytic viruses for high-grade glioma.
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DOI：
10.3389/fcell.2023.1271575
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发表时间：
2023
影响因子：
5.5
通讯作者：
Bernstock, Joshua D.
中科院分区：
文献类型：
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作者：
Karandikar, Paramesh V.;Suh, Lyle;Gerstl, Jakob V. E.;Blitz, Sarah E.;Qu, Qing Rui;Won, Sae-Yeon;Gessler, Florian A.;Arnaout, Omar;Smith, Timothy R.;Peruzzi, Pier Paolo;Yang, Wei;Friedman, Gregory K.;Bernstock, Joshua D.
溶瘤病毒（OV）疗法是治疗中枢神经系统（CNS）内常规治疗难治性癌症（如胶质母细胞瘤）的新方法。尽管OVs已获得监管机构批准用于中枢神经系统，但其疗效受到递送、免疫反应不足/过度活跃以及大多数中枢神经系统恶性肿瘤的“免疫冷”性质等障碍的阻碍。SUMO，小泛素样修饰物，是一个蛋白家族，作为多种关键生理过程的高水平调节剂，包括宿主免疫反应。SUMO通路也与野生型病毒和中枢神经系统恶性肿瘤的发病机制有关。因此，OV生物学与SUMO通路的交叉使得SUMO疗法作为单独或与其他免疫治疗剂协同增强OV疗效的辅助疗法特别有趣。因此，作者在此提供：1)概述SUMO途径及其在中枢神经系统恶性肿瘤中的作用；2)描述针对cns的OVs的现状；3)描述SUMO通路与病毒生命周期和宿主免疫应答之间的相互作用。
Oncolytic viral (OV) therapies are promising novel treatment modalities for cancers refractory to conventional treatment, such as glioblastoma, within the central nervous system (CNS). Although OVs have received regulatory approval for use in the CNS, efficacy is hampered by obstacles related to delivery, under-/over-active immune responses, and the “immune-cold” nature of most CNS malignancies. SUMO, the Small Ubiquitin-like Modifier, is a family of proteins that serve as a high-level regulator of a large variety of key physiologic processes including the host immune response. The SUMO pathway has also been implicated in the pathogenesis of both wild-type viruses and CNS malignancies. As such, the intersection of OV biology with the SUMO pathway makes SUMOtherapeutics particularly interesting as adjuvant therapies for the enhancement of OV efficacy alone and in concert with other immunotherapeutic agents. Accordingly, the authors herein provide: 1) an overview of the SUMO pathway and its role in CNS malignancies; 2) describe the current state of CNS-targeted OVs; and 3) describe the interplay between the SUMO pathway and the viral lifecycle and host immune response.
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影响因子：
16.6
作者：
Bellail, Anita C.;Olson, Jeffrey J.;Hao, Chunhai
通讯作者：
Hao, Chunhai
影响因子：
10.1
作者：
Chiocca EA;Rabkin SD
通讯作者：
Rabkin SD
DOI：
10.1177/0271678x15609939
发表时间：
2016-02
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
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作者：
Bernstock JD;Lee YJ;Peruzzotti-Jametti L;Southall N;Johnson KR;Maric D;Volpe G;Kouznetsova J;Zheng W;Pluchino S;Hallenbeck JM
通讯作者：
Hallenbeck JM
DOI：
10.1093/noajnl/vdad081
发表时间：
2023-01
期刊：
NEURO-ONCOLOGY ADVANCES
影响因子：
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作者：
Bernstock, Joshua D.;Blitz, Sarah E.;Hoffman, Samantha E.;Gerstl, Jakob V. E.;Chiocca, E. Antonio;Friedman, Gregory K.
通讯作者：
Friedman, Gregory K.
影响因子：
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作者：
通讯作者：
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