Effect of three alcohol doses on breathing during sleep in 30-49 year old nonobese snorers and nonsnorers.
Effect of three alcohol doses on breathing during sleep in 30-49 year old nonobese snorers and nonsnorers.
复制标题
三种酒精剂量对 30-49 岁非肥胖打鼾者和非打鼾者睡眠期间呼吸的影响。
DOI：
10.1111/j.1530-0277.1989.tb00347.x
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Hiller,FC
中科院分区：
文献类型：
--
作者：
Scrima,L;Hartman,PG;Hiller,FC
为了测试酒精摄入和打鼾对深度呼吸障碍（SDB）的影响，研究了31名30 - 49岁的非肥胖健康男性（15名打鼾者，16名非打鼾者）在酒精摄入后的睡眠和呼吸。受试者在晚上就寝前接受安慰剂、0.32、0.65和0.81 g酒精/kg体重，每种剂量在重复测量平衡设计中的四个非连续夜晚之一给予。每晚，通过记录肋间表面肌电图（EMG）的呼吸努力、口腔和MMI呼吸器的通气以及耳血氧计（BIOX III）的动脉血氧饱和度（SaO 2）来评估呼吸。打鼾者具有显著的：安慰剂和每次饮酒后，与无打鼾者相比，（a）总SDB更高，（B）阻塞性深度呼吸暂停（OSA）更高，（c）最低SaO 2更低。每次饮酒后打鼾者比不打鼾者有更多的缺氧事件，但安慰剂后没有。增加酒精剂量仅在打鼾者中引起最低SaO 2的统计学显著性降低（p= 0.0004），但这种降低很小，可能不具有临床意义。酒精并没有导致睡眠呼吸暂停和缺氧事件的显著增加，打鼾者和非打鼾者对睡眠呼吸暂停和缺氧事件的影响也没有差异。因为这项实验只包括30-49岁的非肥胖男性，这些结果并不意味着酒精对肥胖受试者或50岁以上的受试者没有显著影响。
To test the effect of alcohol ingestion and snoring on deep‐disordered breathing (SDB), the sleep and respiration of 31 nonobese healthy males ages 30‐49 (15 snorers, 16 nonsnorers) were studied overnight after alcohol ingestion. Subjects received placebo, 0.32, 0.65, and 0.81 g alcohol/kg body weight prior to their evening bedtime, with each dose given on one of four nonconsecutive nights in a repeated‐measures counterbalanced design. On each night, respiration was assessed by recording respiratory effort from inter‐costal surface electromyography (EMG), ventilation from oral and MMI thermistors, and arterial oxygen saturation (SaO2) from an ear oximeter (BIOX III). Snorers had significantly: (a) more total SDB, (b) more obstructive deep apnea (OSA), and (c) lower minimum SaO2than nonsnorers after the placebo and each alcohol dose. Snorers had more hypoxic events than nonsnorers after each alcohol dose but not afterplacebo.Increasing alcohol dose caused a statistically significant (p= 0.0004) decrease in minimum SaO2in snorers only, but this decrease was small and probably not clinically important. Alcohol did not cause significant increases in SDB and hypoxic events, and did not have different effects on SDB and hypoxic events for snorers versus nonsnorers. Because this experiment included only nonobese 30–49‐year‐old males, these results do not imply that alcohol has no significant effects on obese subjects or those older than 50.