FANCF methylation contributes to chemoselectivity in ovarian cancer
FANCF methylation contributes to chemoselectivity in ovarian cancer
复制标题
DOI：
10.1016/s1535-6108(03)00111-9
复制
发表时间：
2003-05-01
期刊：
影响因子：
50.3
通讯作者：
Wei, MJ
中科院分区：
文献类型：
--
作者：
Olopade, OI;Wei, MJ
卵巢癌肿瘤进展的新模型涉及异常FANCF启动子甲基化，该甲基化与Fanconi-anemia-BRCA途径的基因沉默和破坏相关。该途径的中断在卵巢癌中从头发生，可能有助于对铂盐的选择性敏感性。
A new model of ovarian cancer tumor progression implicates aberrantFANCFpromoter methylation that is associated with gene silencing and disruption of the Fanconi-anemia-BRCA pathway. Disruption of the pathway occurs de novo in ovarian cancers and may contribute to selective sensitivity to platinum salts.