Prenatal Ambient Air Pollutant Mixture Exposure and Early School-age Lung Function.
Prenatal Ambient Air Pollutant Mixture Exposure and Early School-age Lung Function.
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产前环境空气污染物混合物暴露与学龄期早期肺功能。
DOI：
10.1097/ee9.0000000000000249
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发表时间：
2023-04
影响因子：
3.6
通讯作者：
Wright, Rosalind J.
中科院分区：
文献类型：
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作者：
Hsu, Hsiao-Hsien Leon;Wilson, Ander;Schwartz, Joel;Kloog, Itai;Wright, Robert O.;Coull, Brent A.;Wright, Rosalind J.
将产前环境空气污染与儿童肺功能联系起来的研究主要一次考虑一种污染物。现实生活中接触的是污染物及其化学成分的混合物；不考虑联合效应/共同暴露的效应修改会导致误导性结果。分析包括从美国马萨诸塞州波士顿的两家医院和附属社区卫生中心招募的 198 名母子夫妻。使用基于卫星的混合化学传输模型估算每日产前污染物暴露量，包括二氧化氮 (NO2)、臭氧 (O3) 和细颗粒成分（元素碳 [EC]、有机碳 [OC]、硝酸盐 [NO3–]、硫酸盐 [SO42–] 和铵 [NH4+]）。肺活量测定在6.99±0.89岁时进行； 1 秒用力呼气量 (FEV1)、用力肺活量 (FVC) 和用力呼气中期流量 (FEF25-75) z 分数考虑了年龄、性别、身高和种族/民族。我们使用贝叶斯核机器回归分布滞后模型 (BKMR-DLM) 检查了每周平均产前污染混合物水平与结果之间的关联，以确定每个成分的敏感性窗口，并估计潜在复杂的混合物暴露-反应关系，包括非线性效应和暴露之间的相互作用。我们还使用 BKMR-DLM 得出的时间加权混合成分水平进行了线性回归模型，并根据母亲年龄、教育程度、围产期吸烟和体温进行了调整。大多数母亲是西班牙裔 (63%) 或黑人 (21%)，受教育年限≤12 年 (67%)。 BKMR-DLM 发现妊娠 18-22 周时 O3 暴露对预测较低的 FEV1/FVC 具有显着影响。线性回归发现 O3、NH4+ 和 OC 分别与 FEV1/FVC、FEV1 和 FEF25-75 降低显着相关。没有证据表明污染物之间存在相互作用。在这个多污染物模型中，产前 O3、OC 和 NH4+ 与儿童早期肺功能下降的关系最为密切。
Research linking prenatal ambient air pollution with childhood lung function has largely considered one pollutant at a time. Real-life exposure is to mixtures of pollutants and their chemical components; not considering joint effects/effect modification by co-exposures contributes to misleading results. Analyses included 198 mother-child dyads recruited from two hospitals and affiliated community health centers in Boston, Massachusetts, USA. Daily prenatal pollutant exposures were estimated using satellite-based hybrid chemical-transport models, including nitrogen dioxide(NO2), ozone(O3), and fine particle constituents (elemental carbon [EC], organic carbon [OC], nitrate [NO3–], sulfate [SO42–], and ammonium [NH4+]). Spirometry was performed at age 6.99 ± 0.89 years; forced expiratory volume in 1s (FEV1), forced vital capacity (FVC), and forced mid-expiratory flow (FEF25-75) z-scores accounted for age, sex, height, and race/ethnicity. We examined associations between weekly-averaged prenatal pollution mixture levels and outcomes using Bayesian Kernel Machine Regression-Distributed Lag Models (BKMR-DLMs) to identify susceptibility windows for each component and estimate a potentially complex mixture exposure-response relationship including nonlinear effects and interactions among exposures. We also performed linear regression models using time-weighted-mixture component levels derived by BKMR-DLMs adjusting for maternal age, education, perinatal smoking, and temperature. Most mothers were Hispanic (63%) or Black (21%) with ≤12 years of education (67%). BKMR-DLMs identified a significant effect for O3 exposure at 18–22 weeks gestation predicting lower FEV1/FVC. Linear regression identified significant associations for O3, NH4+, and OC with decreased FEV1/FVC, FEV1, and FEF25-75, respectively. There was no evidence of interactions among pollutants. In this multi-pollutant model, prenatal O3, OC, and NH4+ were most strongly associated with reduced early childhood lung function.