A new model for dermatitis herpetiformis that uses HLA-DQ8 transgenic NOD mice.
A new model for dermatitis herpetiformis that uses HLA-DQ8 transgenic NOD mice.
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使用 HLA-DQ8 转基因 NOD 小鼠的疱疹样皮炎新模型。
DOI：
10.1172/jci21055
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Murray,JosephA
中科院分区：
文献类型：
--
作者：
Marietta,Eric;Black,Kay;Camilleri,Michael;Krause,Patricia;Rogers3rd,RoyS;David,Chella;Pittelkow,MarkR;Murray,JosephA
Dermatitis herpetiformis (DH) is an autoimmune blistering skin disorder that is associated with gluten sensitivity. It presents as a papulovesicular rash and is often associated with enteropathy. The rash resolves when the patient is placed on a gluten-free diet and/or dapsone. DH, as well as celiac disease, is tightly associated with DQ2 and DQ8. A novel mouse model for DH is described that utilizes the NOD background and the HLA-DQ8 transgene. The addition of DQ8 contributes sensitivity to gliadin, and the addition of the NOD background contributes to autoimmunity and pathogenesis. Fifteen NOD DQ8+ mice of 90 that were sensitized to gluten developed blistering pathology similar to that seen in DH. Neutrophil infiltration of the dermis, deposition of IgA at the dermal-epidermal junction, and a complete reversal of the blistering phenomenon with the administration of a gluten-free diet with or without dapsone were observed. None of the 3 blistering mice examined had small-bowel pathology. This animal model of DH will be useful to determine the specificity of the IgA deposits, as well as the pathogenic mechanisms that occur in the skin as a result of gluten ingestion.
