Natural history of Helicobacter pylori infection
Natural history of Helicobacter pylori infection
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DOI：
10.1016/j.dld.2008.02.035
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发表时间：
2008-07-01
影响因子：
4.5
通讯作者：
Piazuelo, M. B.
中科院分区：
文献类型：
--
作者：
Correa, P.;Piazuelo, M. B.
本报告描述了不同人群幽门螺杆菌感染引起的慢性胃炎的模式。代表癌前级联的全范围病变在低社会经济背景的人群中非常普遍，经历了非常高的胃癌风险，如在拉丁美洲安第斯山脉所见。在高社会经济标准和高癌症风险的人群中，如日本和韩国，癌前级联占主导地位，“早期”癌症也经常被诊断出来。一些报告描述频繁的语料库萎缩，在前一组不突出。所谓的非洲之谜出现在低社会经济标准的人群中，通常生活在低海拔地区，感染率高，但癌症和癌前病变的发病率低。在从高癌症风险向低癌症风险过渡的人群中，十二指肠溃疡和胃窦非萎缩性胃炎是常见的。在癌症风险较低的富裕社会，如西欧、澳大利亚和北美，与低毒力幽门螺杆菌基因型相关的轻度非萎缩性胃炎占主导地位。胃炎的不同表型可能反映了我们物种生态的长期变化。(c) 2008年Editrice gastroenteritaliana S.r.l, Elsevier Ltd.出版版权所有。
This report describes the modalities of chronic gastritis induced by Helicobacter pylori infection in different populations. The full gamut of lesions representing the precancerous cascade is very prevalent in populations of low socioeconomic background experiencing very high gastric cancer risk, as seen in the Latin American Andes Mountains. In populations of high socioeconomic standards and high cancer risk, such as Japan and Korea, the precancerous cascade predominates and "early" cancers are also diagnosed frequently. Some reports describe frequent corpus atrophy, not prominent in the former group. The so-called African enigma is seen in populations of low socioeconomic standards, usually living at low altitudes, with high prevalence of infection but low frequency of cancer and precancerous lesions. In populations in transition from high to low cancer risk, duodenal ulcer and antral non-atrophic gastritis are frequently seen. In affluent societies at low risk of cancer, such as Western Europe, Australia and North America, mild non-atrophic gastritis associated with low virulence Helicobacter pylori genotypes predominate. The varied phenotypes of gastritis may reflect secular changes in the ecology of our species. (c) 2008 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.