Together Forever: Bacterial-Viral Interactions in Infection and Immunity.
Together Forever: Bacterial-Viral Interactions in Infection and Immunity.
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永远在一起：感染和免疫中的细菌-病毒相互作用。
DOI：
10.3390/v10030122
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发表时间：
2018-03-10
期刊：
影响因子：
--
通讯作者：
Gewirtz AT
中科院分区：
文献类型：
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作者：
Shi Z;Gewirtz AT
大多数病毒首先在粘膜表面遇到宿主细胞，粘膜表面通常由统称为微生物群的复杂微生物生态系统定殖。最近的研究表明，微生物群在介导宿主-病毒相互作用和决定这些接触的结果方面起着重要作用。这篇综述概述了最近描述的细菌和病毒如何相互影响的例子，特别是在感染过程中。从机制上讲，这些作用可广泛归类为反映直接细菌-病毒相互作用和/或涉及微生物对先天性和/或适应性免疫的影响。
Most viruses first encounter host cells at mucosal surfaces, which are typically colonized by a complex ecosystem of microbes collectively referred to as the microbiota. Recent studies demonstrate the microbiota plays an important role in mediating host–viral interactions and determining the outcomes of these encounters. This review outlines recently described examples of how bacteria and viruses impact each other particularly during infectious processes. Mechanistically, these effects can be broadly categorized as reflecting direct bacterial–viral interactions and/or involving microbial impacts upon innate and/or adaptive immunity.