Insight into the frequent occurrence of dura mater graft-associated Creutzfeldt-Jakob disease in Japan
Insight into the frequent occurrence of dura mater graft-associated Creutzfeldt-Jakob disease in Japan
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DOI：
10.1136/jnnp-2012-304850
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发表时间：
2013-10-01
影响因子：
11
通讯作者：
Yamada, Masahito
中科院分区：
文献类型：
--
作者：
Hamaguchi, Tsuyoshi;Sakai, Kenji;Yamada, Masahito
全球超过60%的与硬脑膜移植物（dCJD）相关的克雅氏病（CJD）患者在日本被诊断出来。在日本，硬脑膜移植的显著频率可能导致dCJD的发病率升高，但该手术在日本不成比例使用的原因尚不清楚。我们调查dCJD患者在日本和其他地方的差异，以帮助解释更频繁地使用尸体硬脑膜和dCJD在日本的高发病率。MethodsWe获得的数据dCJD患者在日本的日本国家CJD监测计划和dCJD患者在其他国家从现存的文献。我们比较了人口，临床和病理特征的dCJD患者在日本与那些从其他countries.ResultsData获得了142 dCJD患者在日本和53 dCJD患者在其他地方。硬脑膜移植前的医疗条件在日本和其他国家之间有显著差异（p
ObjectiveMore than 60% of patients worldwide with Creutzfeldt-Jakob disease (CJD) associated with dura mater graft (dCJD) have been diagnosed in Japan. The remarkable frequency of dura mater grafts in Japan may possibly contribute to the elevated incidence of dCJD, but reasons for the disproportionate use of this procedure in Japan remain unclear. We investigated differences between dCJD patients in Japan and those elsewhere to help explain the more frequent use of cadaveric dura mater and the high incidence of dCJD in Japan.MethodsWe obtained data on dCJD patients in Japan from the Japanese national CJD surveillance programme and on dCJD patients in other countries from the extant literature. We compared the demographic, clinical and pathological features of dCJD patients in Japan with those from other countries.ResultsData were obtained for 142 dCJD patients in Japan and 53 dCJD patients elsewhere. The medical conditions preceding dura mater graft transplantation were significantly different between Japan and other countries (p