ASYMMETRIC-SYNTHESIS OF ALPHA-SUBSTITUTED BENZYL ALCOHOLS VIA THE STEREOSELECTIVE ADDITION OF NUCLEOPHILES TO HOMOCHIRAL TRICARBONYL(ETA-6-O-TRIALKYLSILYLBENZALDEHYDE)CHROMIUM(O) COMPLEXES
ASYMMETRIC-SYNTHESIS OF ALPHA-SUBSTITUTED BENZYL ALCOHOLS VIA THE STEREOSELECTIVE ADDITION OF NUCLEOPHILES TO HOMOCHIRAL TRICARBONYL(ETA-6-O-TRIALKYLSILYLBENZALDEHYDE)CHROMIUM(O) COMPLEXES
复制标题
DOI：
10.1039/p19900000393
复制
发表时间：
1990-02-01
期刊：
影响因子：
--
通讯作者：
GOODFELLOW, CL
中科院分区：
文献类型：
--
作者：
DAVIES, SG;GOODFELLOW, CL
在存在或不存在强路易斯酸的情况下，亲核剂与tricarbonyl(.eta.6-o-trialkylsilybenzaldehyde)chromium(0)络合物的加成反应具有互补的非对映选择性。高手性醛配合物的现成，通过L-缬氨醇的经典拆分，允许合成具有高对映体过剩的α-取代苯甲醇。
The addition of nucleophiles to tricarbonyl(.eta.6-o-trialkylsilybenzaldehyde)chromium(0) complexes proceeds with complementary diastereoselectivities in the presence or absence of strong Lewis acids. The ready availability of homochiral aldehyde complexes, via classical resolution with L-valinol, permits the synthesis of alpha substituted benzyl alcohols with high enantiomeric excesses.