Chimpanzee reservoirs of pandemic and nonpandemic HIV-1
Chimpanzee reservoirs of pandemic and nonpandemic HIV-1
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DOI：
10.1126/science.1126531
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发表时间：
2006-07-28
期刊：
影响因子：
56.9
通讯作者：
Hahn, Beatrice H.
中科院分区：
文献类型：
--
作者：
Keele, Brandon F.;Van Heuverswyn, Fran;Hahn, Beatrice H.
人类免疫缺陷病毒1型（HIV-1）是引起人类获得性免疫缺陷综合征（艾滋病）的一种人畜共患感染，其比例和社会影响惊人。然而，关于其天然储量的不确定性仍然存在。与HIV-1最密切相关的病毒是一种猿类免疫缺陷病毒（SIV），迄今为止仅在黑猩猩亚种类人猿（Pan troglodytes）的圈养成员中发现。在这里，我们报告了在喀麦隆南部野生生活的类人猿粪便样本中检测到SIVcpz抗体和核酸，其中一些社区的患病率达到29%至35%。通过对地方性SIVcpz毒株的序列分析，我们可以将大流行（M组）和非大流行（N组）HIV-1的起源追溯到不同的、地理上孤立的黑猩猩群落。这些发现表明，类人猿是HIV-1的天然储存库。
Human immunodeficiency virus type 1 (HIV-1), the cause of human acquired immunodeficiency syndrome ( AIDS), is a zoonotic infection of staggering proportions and social impact. Yet uncertainty persists regarding its natural reservoir. The virus most closely related to HIV-1 is a simian immunodeficiency virus ( SIV) thus far identified only in captive members of the chimpanzee subspecies Pan troglodytes troglodytes. Here we report the detection of SIVcpz antibodies and nucleic acids in fecal samples from wild-living P.t. troglodytes apes in southern Cameroon, where prevalence rates in some communities reached 29 to 35%. By sequence analysis of endemic SIVcpz strains, we could trace the origins of pandemic ( group M) and nonpandemic ( group N) HIV-1 to distinct, geographically isolated chimpanzee communities. These findings establish P. t. troglodytes as a natural reservoir of HIV-1.