Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2.
Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2.
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DOI：
10.4161/nucl.18926
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发表时间：
2012-01
期刊：
影响因子：
--
通讯作者：
Ohno S
中科院分区：
文献类型：
--
作者：
Izumi N;Yamashita A;Ohno S
磷脂酰肌醇3-激酶相关蛋白激酶（PIKK）家族的蛋白质被各种细胞应激激活，包括DNA损伤、提前终止密码子和营养状态，并诱导适当的细胞应答。PIKK功能在维持基因组完整性、准确基因表达和适当控制细胞生长/增殖方面的重要性已确立。最近，ATP酶相关的多种细胞活性（AAA+）蛋白RUVBL 1和RUVBL 2（RUVBL 1/2）已被证明是PIKK的常见调节剂。RUVBL 1/2复合物通过与PIKK的物理相互作用和通过控制PIKK mRNA水平来调节PIKK介导的应激反应。本文综述了PIKKs在应激反应中的功能，并介绍了RUVBL 1/2复合物对PIKKs的整合调控的生理意义。我们还讨论了一个假定的“PIKK监管分子伴侣复合物”，包括其他PIKK监管机构，热休克蛋白90和Tel 2复合物。
Proteins of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family are activated by various cellular stresses, including DNA damage, premature termination codon and nutritional status, and induce appropriate cellular responses. The importance of PIKK functions in the maintenance of genome integrity, accurate gene expression and the proper control of cell growth/proliferation is established. Recently, ATPase associated diverse cellular activities (AAA+) proteins RUVBL1 and RUVBL2 (RUVBL1/2) have been shown to be common regulators of PIKKs. The RUVBL1/2 complex regulates PIKK-mediated stress responses through physical interactions with PIKKs and by controlling PIKK mRNA levels. In this review, the functions of PIKKs in stress responses are outlined and the physiological significance of the integrated regulation of PIKKs by the RUVBL1/2 complex is presented. We also discuss a putative “PIKK regulatory chaperone complex” including other PIKK regulators, Hsp90 and the Tel2 complex.
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影响因子：
4.8
作者：
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通讯作者：
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影响因子：
11.4
作者：
Bauer, A;Chauvet, S;Pradel, J
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影响因子：
21.3
作者：
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通讯作者：
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影响因子：
56.9
作者：
Azzalin, Claus M.;Reichenbach, Patrick;Lingner, Joachim
通讯作者：
Lingner, Joachim
DOI：
10.1083/jcb.200708110
发表时间：
2008-02-11
期刊：
The Journal of cell biology
影响因子：
--
作者：
Boulon S;Marmier-Gourrier N;Pradet-Balade B;Wurth L;Verheggen C;Jády BE;Rothé B;Pescia C;Robert MC;Kiss T;Bardoni B;Krol A;Branlant C;Allmang C;Bertrand E;Charpentier B
通讯作者：
Charpentier B