Relaxin reduces fibrosis in models of progressive and established hepatic fibrosis.
Relaxin reduces fibrosis in models of progressive and established hepatic fibrosis.
复制标题
松弛素可减少进行性和已形成的肝纤维化模型中的纤维化。
DOI：
10.1111/j.1749-6632.2008.03783.x
复制
发表时间：
2009-04
影响因子：
5.2
通讯作者：
Tuma, Dean J.
中科院分区：
文献类型：
--
作者：
Bennett, Robert G.;Heimann, Dean G.;Tuma, Dean J.
The effect of relaxin administration before (prevention) or after (treatment) the establishment of hepatic fibrosis in a mouse model was examined. In the prevention study, relaxin reduced collagen and smooth muscle actin (SMA) content, and significantly reduced serum levels of the liver enzymes ALT and AST. In the treatment study, relaxin for 1 week reduced collagen and SMA, but not liver enzyme levels. Relaxin for 2 weeks had no significant effect. In conclusion, the data suggest that relaxin treatment before fibrosis can reduce collagen and improve liver function, but that there is little effect of short-term relaxin treatment after fibrosis is established.
影响因子：
24.5
作者：
Williams, EJ;Benyon, RC;Iredale, JP
通讯作者：
Iredale, JP
影响因子：
5.8
作者：
Bennett, RG;Kharbanda, KK;Tuma, DJ
通讯作者：
Tuma, DJ
影响因子：
5.8
作者：
Bennett, Robert G.;Dalton, Shana R.;Tuma, Dean J.
通讯作者：
Tuma, Dean J.