Insulin regulates plasma ghrelin concentration.
Insulin regulates plasma ghrelin concentration.
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DOI：
10.1210/jcem.87.8.8879
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发表时间：
2002-08
期刊：
影响因子：
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通讯作者：
M. Saad;Basem Z Bernaba;C. Hwu;Sujata D Jinagouda;Salwa Fahmi;E. Kogosov;Rima Boyadjian
中科院分区：
文献类型：
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作者：
M. Saad;Basem Z Bernaba;C. Hwu;Sujata D Jinagouda;Salwa Fahmi;E. Kogosov;Rima Boyadjian
Ghrelin是一种新型的胃肽，具有促食欲和促脂肪生成的作用。血浆ghrelin受营养状况的影响，并被认为在调节食物摄入和体重方面发挥作用。我们在8名年龄为46 ± 4岁的受试者（5名男性，3名女性）中检测了持续输注胰岛素（40 mU/m（2）/min）2小时同时维持优泌肽对血浆ghrelin的影响（平均值± SEM）。血浆胰岛素在输注期间从78 +/- 9升高至564 +/- 23 pmol/L，并在停止胰岛素输注后迅速恢复至基础值。90分钟时，血浆ghrelin从85 +/- 28降至61 +/- 18 pmol/L（p < 0.01），并在胰岛素输注停止后持续抑制15分钟。随后，血浆ghrelin在60分钟内迅速上升至接近基础值（81 +/- 23 pmol/L）。在所有受试者中均观察到胰岛素和生长激素释放肽之间的相互关系，胰岛素诱导的生长激素释放肽最大抑制范围为19 - 64%（平均值32 +/- 5），发生在开始胰岛素输注后90-135分钟（中位数120）。这些结果表明，胰岛素是血浆ghrelin的生理和动态调节剂，胰岛素血症可能介导营养状况对其浓度的影响。
Ghrelin is a novel gastric peptide which stimulates growth hormone and has orexigenic and adipogenic properties. Plasma ghrelin is influenced by nutritional status and is thought to play a role in regulating food intake and body weight. We examined the effect of infusing insulin (40 mU/m(2)/min) for 2 hours while maintaining euglycemia on plasma ghrelin in 8 subjects (5 M, 3 F) aged 46 +/- 4 yrs (mean +/- SEM). Plasma insulin increased from 78 +/- 9 to 564 +/- 23 pmol/L during and returned rapidly to basal values after stopping the insulin infusion. Plasma ghrelin decreased from 85 +/- 28 to 61 +/- 18 pmol/L (p < 0.01) by 90 minutes of and continued to be suppressed for 15 minutes after the insulin infusion was discontinued. Subsequently, plasma ghrelin rose rapidly to near-basal values (81 +/- 23 pmol/L) within 60 minutes. The reciprocal relation between insulin and ghrelin was observed consistently in all subjects with the maximum insulin-induced suppression of ghrelin ranging from 19 to 64% (mean 32 +/- 5) and occurring 90-135 minutes after starting the insulin infusion (median 120). These findings indicate that insulin is a physiological and dynamic modulator of plasma ghrelin and that insulinemia possibly mediates the effect of nutritional status on its concentration.