Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival:: an overview of the randomised trials
Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival:: an overview of the randomised trials
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DOI：
10.1016/s0140-6736(05)66544-0
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发表时间：
2005-05-14
期刊：
影响因子：
168.9
通讯作者：
Caffier, H
中科院分区：
文献类型：
--
作者：
Abe, O;Abe, R;Caffier, H
背景在早期乳腺癌中，局部治疗的变化会显著影响局部复发的风险，也会影响长期乳腺癌死亡率。为了检验这种关系，进行了协作荟萃分析，根据个体患者的数据，相关的随机试验，开始于1995年。方法信息是在42 000名妇女在78个随机治疗比较（放疗与不放疗，23 500;更多与更少的手术，9300;更多的手术与放疗，9300）。确定了24种局部治疗比较。为了帮助与局部（即局部）复发的乳腺癌死亡率的影响，这些进行了分组，根据是否5年局部复发的风险超过10%（10%，25 000名妇女）。然而，在差异很小（10%）的比较中，5年局部复发风险为7%，对照组为26%（绝对降低19%），15年乳腺癌死亡风险为44.6%，对照组为49.5%（绝对降低5.0%，SE 0.8，2 p <0.05）。
Background in early breast cancer, variations in local treatment that substantially affect the risk of locoregional recurrence could also affect long-term breast cancer mortality. To examine this relationship, collaborative meta-analyses were undertaken, based on individual patient data, of the relevant randomised trials that began by 1995.Methods Information was available on 42 000 women in 78 randomised treatment comparisons (radiotherapy vs no radiotherapy, 23 500; more vs less surgery, 9300; more surgery vs radiotherapy, 9300). 24 types of local treatment comparison were identified. To help relate the effect on local (ie, locoregional) recurrence to that on breast cancer mortality, these were grouped according to whether or not the 5-year local recurrence risk exceeded 10% (10%, 25 000 women).Findings About three-quarters of the eventual local recurrence risk occurred during the first 5 years. In the comparisons that involved little (10%) differences, however, 5-year local recurrence risks were 7% active versus 26% control (absolute reduction 19%), and 15-year breast cancer mortality risks were 44.6% versus 49.5% (absolute reduction 5.0%,SE 0.8, 2p