The influence of chronic illnesses on the incidence of invasive pneumococcal disease in adults
The influence of chronic illnesses on the incidence of invasive pneumococcal disease in adults
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DOI：
10.1086/431521
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发表时间：
2005-08-01
影响因子：
6.4
通讯作者：
Whitney, CG
中科院分区：
文献类型：
--
作者：
Kyaw, MH;Rose, CE;Whitney, CG
肺炎球菌病在有某些合并症的人中更常见，也更致命。我们使用1999年和2000年的活动性细菌核心监测（ABC）和国家健康访问调查（NHIS）的数据，以确定健康成人（≥ 18岁）和各种高危状况的成人中侵袭性肺炎球菌疾病的发病率。在控制了年龄、种族和其他慢性疾病的情况下，将患有特定慢性疾病的人患侵袭性肺炎球菌疾病的风险与健康成年人进行了比较。总体发病率（例/100，000人）在健康成人中为8.8，在糖尿病成人中为51.4，在慢性肺病成人中为62.9，在慢性心脏病成人中为93.7，在酗酒成人中为100.4。在评估的高危人群中，患有实体癌（300.4）、艾滋病毒/艾滋病（422.9）和血液癌（503.1）的成年人的风险最高。在患有慢性肺病、糖尿病和实体癌的成年人中，发病率随着年龄的增长而增加。无论是在健康成人还是慢性病成人中，黑人成人的发病率都高于白色成人。这些数据支持向这些高危人群提供肺炎球菌疫苗的建议，并强调需要为免疫功能低下的人制定更好的预防策略。
Pneumococcal disease is more frequent and more deadly in persons with certain comorbidities. We used 1999 and 2000 data from the Active Bacterial Core surveillance (ABCs) and the National Health Interview Survey (NHIS) to determine rates of invasive pneumococcal disease in healthy adults (>= 18 years old) and in adults with various high-risk conditions. The risks of invasive pneumococcal disease in persons with specific chronic illnesses was compared with that in healthy adults, controlling for age, race, and the other chronic illnesses. Overall incidence rates, in cases/100,000 persons, were 8.8 in healthy adults, 51.4 in adults with diabetes, 62.9 in adults with chronic lung disease, 93.7 in adults with chronic heart disease, and 100.4 in adults who abused alcohol. Among the high-risk groups evaluated, risk was highest in adults with solid cancer (300.4), HIV/AIDS (422.9), and hematological cancer (503.1). Incidence rates increased with advancing age in adults with chronic lung disease, diabetes, and solid cancer. Black adults had higher incidence rates than white adults, both in healthy adults and in adults with chronic illnesses. These data support recommendations to provide pneumococcal vaccine to persons in these at-risk groups and underscore the need for better prevention strategies for immunocompromised persons.