Growth hormone in the tumor microenvironment
Growth hormone in the tumor microenvironment
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DOI：
10.20945/2359-3997000000186
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发表时间：
2019-11-01
期刊：
影响因子：
--
通讯作者：
Melmed, Shlomo
中科院分区：
文献类型：
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作者：
Chesnokova, Vera;Melmed, Shlomo
肿瘤的发展是一个多步骤的过程，其中局部机制使体细胞突变在癌前阶段。一旦肿瘤发展，它就会变成一个由多种细胞类型组成的复杂器官。恶性和非转化细胞和组织之间的相互作用产生了肿瘤微环境（TME），其包括上皮癌细胞、癌症干细胞、非肿瘤细胞、基质细胞、免疫炎性细胞、血液和淋巴管网络以及细胞外基质。我们回顾报告，并提出一个假设，假定参与生长激素（GH）在外地癌变。我们讨论了生长激素对TME的贡献，促进上皮细胞向间质细胞转化，未修复DNA损伤的积累，肿瘤血管分布和对治疗的抵抗。
Tumor development is a multistep process whereby local mechanisms enable somatic mutations during preneoplastic stages. Once a tumor develops, it becomes a complex organ composed of multiple cell types. Interactions between malignant and non-transformed cells and tissues create a tumor microenvironment (TME) comprising epithelial cancer cells, cancer stem cells, non-tumorous cells, stromal cells, immune-inflammatory cells, blood and lymphatic vascular network, and extracellular matrix. We review reports and present a hypothesis that postulates the involvement of growth hormone (GH) in field cancerization. We discuss GH contribution to TME, promoting epithelial-to-mesenchymal transition, accumulation of unrepaired DNA damage, tumor vascularity, and resistance to therapy.