New experimental models of diabetic nephropathy in mice models of type 2 diabetes: efforts to replicate human nephropathy.
New experimental models of diabetic nephropathy in mice models of type 2 diabetes: efforts to replicate human nephropathy.
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DOI：
10.1155/2012/616313
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发表时间：
2012
影响因子：
--
通讯作者：
Batlle D
中科院分区：
文献类型：
--
作者：
Soler MJ;Riera M;Batlle D
糖尿病肾病（diabetic nephropathy，DN）是导致终末期肾病的主要原因。DN的实验模型的使用提供了关于DN的许多方面的有价值的信息，包括病理生理学、进展、相关基因和新的治疗策略。已经鉴定了大量的糖尿病小鼠模型，并且它们的肾脏疾病具有不同程度的特征。大多数2型DN的实验模型有助于研究DN的早期阶段，但这些模型不能再现人类更晚期DN的特征，如肾小球簇中的结节或肾小球硬化。通过基因的交叉、敲低或敲入产生的新的DN实验模型的产生继续为研究DN提供改进的工具。这些模型提供了一个机会，以寻找新的机制，涉及DN的发展，但他们的缺点，以及应认识到。此外，重要的是要认识到遗传背景对各种糖尿病模型中糖尿病和肾脏疾病发展的易感性具有实质性影响。
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. The use of experimental models of DN has provided valuable information regarding many aspects of DN, including pathophysiology, progression, implicated genes, and new therapeutic strategies. A large number of mouse models of diabetes have been identified and their kidney disease was characterized to various degrees. Most experimental models of type 2 DN are helpful in studying early stages of DN, but these models have not been able to reproduce the characteristic features of more advanced DN in humans such as nodules in the glomerular tuft or glomerulosclerosis. The generation of new experimental models of DN created by crossing, knockdown, or knockin of genes continues to provide improved tools for studying DN. These models provide an opportunity to search for new mechanisms involving the development of DN, but their shortcomings should be recognized as well. Moreover, it is important to recognize that the genetic background has a substantial effect on the susceptibility to diabetes and kidney disease development in the various models of diabetes.
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