Oxy‐/Amino‐Difluoromethylthiolation of Alkenes: Synthesis of HCF2S‐Containing Isoxazolines and Pyrazolines
Oxy‐/Amino‐Difluoromethylthiolation of Alkenes: Synthesis of HCF2S‐Containing Isoxazolines and Pyrazolines
复制标题
烯烃的氧-/氨基-二氟甲硫基化：合成含有异恶唑啉和吡唑啉的HCF2S-
DOI：
10.1002/adsc.202200672
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发表时间：
2022-08
影响因子：
5.4
通讯作者：
Li Ya-Min
中科院分区：
文献类型：
--
作者：
Chen Xin;Shen Yun-Tao;Zhao Zhi-Wei;Hou Yu-Jian;Sun Bo-Xun;Fan Tai-Gang;Li Ya-Min
以PhSO_2 SCF_2 H为二氟甲硫醇化试剂，在温和条件下，对β，γ-不饱和肟/腙进行了氧/氨基二氟甲硫醇化反应，合成了含HCF_2S的异恶唑啉和吡唑啉。这样的转换表现出良好的功能组容忍度和可扩展性。提出了可能的机制。
Oxy-/amino-difluoromethylthiolation of β,γ-unsaturated oximes/hydrazones have been developed for construction of HCF2S-containing isoxazolines and pyrazolines by employing PhSO2SCF2H as difluoromethylthiolation reagent under mild conditions. Such transformations exhibit good functional group tolerance and scalability. Possible mechanisms are proposed.