Metal-Free Radical [2+2+1] Cyclization of ortho-Cyanoarylacrylamides with Alkyl Nitriles: Synthesis of Pyrrolo[3,2-c]quinolines
Metal-Free Radical [2+2+1] Cyclization of ortho-Cyanoarylacrylamides with Alkyl Nitriles: Synthesis of Pyrrolo[3,2-c]quinolines
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DOI：
10.1021/acs.orglett.8b03638
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发表时间：
2019-01-18
期刊：
影响因子：
5.2
通讯作者：
Li, Ya-Min
中科院分区：
文献类型：
--
作者：
Yang, Tao;Xia, Wen-Jin;Li, Ya-Min
本文报道了一种新的含双α-C-H键的邻氰基芳基丙烯酰胺的[2 + 2 + 1]自由基环化反应。该反应为氰基取代的吡咯并[3，2-c]-喹啉类化合物的合成提供了新的途径。提出了一种可能的转换机制。
A novel radical [2 + 2 + 1] cyclization of ortho-cyanoarylacrylamides with dual alpha-C-H bonds in alkyl nitriles has been developed. The reaction provides new facile and straightforward access to cyano-substituted pyrrolo[3,2-c]-quinolines, which are important nitrogen-containing poly-heterocycles. A possible mechanism for the transformation is proposed.