Characterization of calreticulin expression in mouse endometrium during embryo implantation.
Characterization of calreticulin expression in mouse endometrium during embryo implantation.
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DOI：
10.4067/s0716-97602009000400012
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发表时间：
2009
影响因子：
6.7
通讯作者：
Shu-Qun Cheng;Jun-lin He;Yanling Dong;Xue-qing Liu;Yubin Ding;Rufei Gao;Yi Tan;Q. Ye;Z. Tian;Ying-Xiong Wang
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文献类型：
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作者：
Shu-Qun Cheng;Jun-lin He;Yanling Dong;Xue-qing Liu;Yubin Ding;Rufei Gao;Yi Tan;Q. Ye;Z. Tian;Ying-Xiong Wang
Calreticulin (CRT), a Ca(2+)-binding storage protein and chaperone in the endoplasmic reticulum, modulates cell adhesiveness and integrin-dependent Ca(2+) signaling. However, the role of CRT during implantation remains poorly understood. In the present study, we characterized the expression of CRT mRNA and the protein in mouse endometria from pregnancy DI to D7. Real-Time PCR and in situ hybridization results showed that the levels of CRT mRNA in the endometria of pregnant mice were significantly higher than those of non-pregnant mice (P)<0.05). These findings suggest that CRT may play an important role in embryo implantation in mice.
