A phosphine mediated sequential annulation process of 2-tosylaminochalcones with MBH carbonates to construct functionalized aza-benzobicyclo[4.3.0] derivatives
A phosphine mediated sequential annulation process of 2-tosylaminochalcones with MBH carbonates to construct functionalized aza-benzobicyclo[4.3.0] derivatives
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膦介导的 2-甲苯磺酰氨基查耳酮与 MBH 碳酸盐的顺序成环过程构建功能化氮杂苯并双环[4.3.0]衍生物
DOI：
10.1039/c6cc10155k
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发表时间：
2017
影响因子：
4.9
通讯作者：
Huang You
中科院分区：
文献类型：
--
作者：
Zhang Qinglong;Zhu Yannan;Jin Hongxing;Huang You
采用一锅法连续催化化学计量合成了一系列含一个季中心的氮杂苯并双环[4.3.0]衍生物，收率高达94%，dr值为20：1。 在该反应中，MBH碳酸酯充当1，2，3-C3正离子。
A novel phosphine mediated sequential annulation process to construct functionalized aza-benzobicyclo[4.3.0] derivatives has been developed involving a one-pot sequential catalytic and stoichiometric process, which generates a series of benzobicyclo[4.3.0] compounds containing one quaternary center with up to 94% yield and 20 : 1 dr value. In this reaction, MBH carbonates act as 1,2,3-C3 synthons.