Writing biology with mutant mice: The monstrous potential of post genomic life
Writing biology with mutant mice: The monstrous potential of post genomic life
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DOI：
10.1016/j.geoforum.2011.03.004
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发表时间：
2013-08-01
期刊：
影响因子：
3.5
通讯作者：
Davies, Gail
中科院分区：
文献类型：
--
作者：
Davies, Gail
社会科学的解释在早期基因组学的生物语法中发现了一种可怕的还原论，“一个野蛮生命的例子，事物的最低限度本质”（Rabinow，1996，第89页）。对这种还原论的关注特别集中在它与现代主义控制概念的联系上;计算，预测和干预个人和群体的生物未来的可能性。然而，后基因组科学的发展轨迹并没有以这种方式展开，这对参与复杂生物数据的生产和整合的科学家以及在批评这种还原论中磨练出来的社会科学家的解释策略提出了挑战。后基因组科学现在是了解生物学中基因与环境之间以及物种与空间之间关系的增殖点，开辟了未来的可能性和思考生命的不同方式。本文探讨了新兴的拓扑结构和时间性的一种形式的后基因组学研究，借鉴民族志研究的国际努力，在功能基因组学，这是使用突变小鼠了解哺乳动物基因功能。使用词汇的怪物从德里达和哈拉维，我建议另一种概念化的怪物在生物学中，其中小鼠在功能基因组学的优势作为一个不断的补充还原语法的基因组学。这种形式的功能基因组学不是寻找事物的最低限度的本质，而是成为生产和组织生物过剩和过剩的一种练习，这是实验性的，corrective的和情感的。在这种背景下，怪物的不确定功能对科学家和社会科学家来说是一种生成催化剂，从这些角度来倾听和参与后基因组生物学的变异景观，生命形式和语言。(C)2011爱思唯尔有限公司版权所有。
Social scientific accounts identified in the biological grammars of early genomics a monstrous reductionism, 'an example of brute life, the minimalist essence of things' (Rabinow, 1996, p. 89). Concern about this reductionism focused particularly on its links to modernist notions of control; the possibility of calculating, predicting and intervening in the biological futures of individuals and populations. Yet the trajectories of the post genomic sciences have not unfolded in this way, challenging scientists involved in the production and integration of complex biological data and the interpretative strategies of social scientists honed in critiquing this reductionism. The post genomic sciences are now proliferating points from which to understand relations in biology, between genes and environments, as well as between species and spaces, opening up future possibilities and different ways of thinking about life. This paper explores the emerging topologies and temporalities of one form of post genomic research, drawing upon ethnographic research on international efforts in functional genomics, which are using mutant mice to understand mammalian gene function. Using vocabularies on the monstrous from Derrida and Haraway, I suggest an alternative conceptualisation of monstrosity within biology, in which the ascendancy of mice in functional genomics acts as a constant supplement to the reductionist grammars of genomics. Rather than searching for the minimalist essence of things, this form of functional genomics has become an exercise in the production and organisation of biological surplus and excess, which is experimental, corporeal and affective. The uncertain functioning of monsters in this contexts acts as a generative catalyst for scientists and social scientists, proliferating perspectives from which to listen to and engage with the mutating landscapes, forms of life, and languages of a post genomic biology. (C) 2011 Elsevier Ltd. All rights reserved.