Anion Recognition as a Supramolecular Switch of Cell Internalization.
Anion Recognition as a Supramolecular Switch of Cell Internalization.
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DOI：
10.1021/jacs.6b11103
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发表时间：
2017-01-11
影响因子：
15
通讯作者：
Mascareñas JL
中科院分区：
文献类型：
--
作者：
Rodríguez J;Mosquera J;Couceiro JR;Nitschke JR;Vázquez ME;Mascareñas JL
设计的寡精氨酸肽在 N 末端配备有六个谷氨酸残基和一个阴离子吡喃，在添加超分子宿主后会触发细胞内化。该宿主与吡喃部分特异性结合，使复合物能够穿过细胞膜。有趣的是，无论是宿主还是客体，所有成分都无法自行穿过细胞膜。
The cell internalization of designed oligoarginine peptides equipped with six glutamic acid residues and an anionic pyranine at the N-terminus is triggered upon addition of a supramolecular host. This host binds specifically to the pyranine moiety, enabling the complex to traverse the cell membrane. Interestingly, none of the components, neither the host nor the guest, are able to cross the cell membrane on their own.