A study on the frequency of olfactory dysfunction
A study on the frequency of olfactory dysfunction
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DOI：
10.1097/00005537-200410000-00017
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发表时间：
2004-10-01
期刊：
影响因子：
2.6
通讯作者：
Hummel, T
中科院分区：
文献类型：
--
作者：
Landis, BN;Konnerth, CG;Hummel, T
目的/假说。该研究的目的是评估嗅觉功能障碍的频率在一个大的代表性人群中没有鼻窦疾病，并调查一般病理状况，药物和衰老对嗅觉的影响程度。研究。设计:前瞻性。方法。根据气味识别测试（“嗅探棒”）报告了来自1240名受试者的结果。受试者以与上呼吸道无关的相对轻微和短暂的主诉来到耳鼻喉科门诊。详细的耳鼻喉科检查结合标准化访谈进一步确定这些患者没有鼻科问题或与鼻窦疾病相关的症状。结果。除了确认年龄、性别和某些耳鼻喉疾病对嗅觉的影响外，研究结果还显示，某些一般疾病（肝病、非耳鼻喉癌症）似乎会影响嗅觉功能，而其他疾病或失调（高血压、心血管问题）对嗅觉的影响很小或没有影响。结论：本研究的数据显示，65岁以下受试者的嗅觉功能障碍比先前报道的更为常见。
Objectives/Hypothesis. Goals of the study were to evaluate the frequency of olfactory dysfunction in a large representative population without sinonasal complaints and to investigate the extent to which general pathological conditions, medications, and aging influence olfaction. Study. Design: Prospective. Methods. Results based on an odor identification test ("Sniffin' Sticks") were reported from 1240 subjects. The subjects presented themselves to an otorhinolaryngology outpatient clinic with relatively mild and transitory complaints unrelated to the upper airways. A detailed otorhinolaryngological examination in combination with a standardized interview further ascertained that these patients had no rhinological problems or symptoms relating to sinonasal disease. Results. Apart from the confirmation of the effects of age, gender, and certain otorhinolaryngological diseases on the sense of smell, the study results revealed that certain general diseases (liver diseases, nonotolaryngological cancers) appear to influence olfactory function, whereas other diseases or disorders have little or no impact on olfaction (hypertension, cardiovascular problems). Conclusion: The data in the study revealed that olfactory dysfunction among subjects under 65 years of age is more frequent than previously reported.