Urinary CD80 Excretion Increases in Idiopathic Minimal-Change Disease
Urinary CD80 Excretion Increases in Idiopathic Minimal-Change Disease
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DOI：
10.1681/asn.2007080836
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发表时间：
2009-02-01
影响因子：
13.6
通讯作者：
Johnson, Richard J.
中科院分区：
文献类型：
--
作者：
Garin, Eduardo H.;Diaz, Leila N.;Johnson, Richard J.
CD80在所有抗原提呈细胞上表达，在许多肾病综合征的实验模型中也存在于足细胞上。我们检测了特发性微小病变病(MCD)患者尿可溶性CD80是否升高。我们收集了复发和缓解期MCD患者、其他肾小球疾病(FSGS、膜增生性肾小球肾炎、IgA肾病和膜性肾病)引起的肾病综合征患者、系统性红斑狼疮患者和正常对照组的尿液和血清样本。复发MCD患者尿sCD80水平显著高于缓解期MCD患者、其他肾小球疾病患者、伴或不伴蛋白尿的系统性红斑狼疮患者及健康对照组。CD80负性调节因子--可溶性CTLA-4在MCD复发组和缓解组的尿液浓度无统计学差异。复发组患者尿sCD80/CTLA-4比值是缓解组的100倍(P<；0.008)。相反，血清可溶性CD80和CTLA-4浓度并不能区分MCD患者的复发和缓解期。结论：特发性MCD患者尿可溶性CD80水平升高，可能与MCD的诊断和发病机制有关。
CD80 is expressed on all antigen-presenting cells and is present on podocytes in a number of experimental models of nephrotic syndrome. We tested whether urinary soluble CD80 increased with idiopathic minimal-change disease (MCD). We collected urine and serum samples from patients with MCD in relapse and in remission, patients with nephrotic syndrome resulting from other glomerular diseases (FSGS, membranoproliferative glomerulonephritis, IgA nephropathy, and membranous nephropathy), patients with systemic lupus erythematosus, and normal control subjects. Urinary concentrations of soluble CD80 in patients with relapsed MCD were significantly higher compared with those observed in patients with MCD in remission, other glomerular diseases, and systemic lupus erythematosus with and without proteinuria and healthy control subjects. Urinary concentrations of soluble CTLA-4, which is a negative regulator of CD80, were not statistically different in patients with relapsed MCD compared with those in remission. The urinary soluble CD80/CTLA-4 ratio was >100-fold higher in patients with relapsed MCD compared with those in remission (P < 0.008). In contrast, serum concentrations of soluble CD80 and CTLA-4 did not distinguish patients with MCD in relapse and in remission. In conclusion, urinary soluble CD80 is elevated in idiopathic MCD, which could be relevant to both diagnosis and pathogenesis.