Comparing the distress thermometer (DT) with the patient health questionnaire (PHQ)-2 for screening for possible cases of depression among patients newly diagnosed with advanced cancer.
Comparing the distress thermometer (DT) with the patient health questionnaire (PHQ)-2 for screening for possible cases of depression among patients newly diagnosed with advanced cancer.
复制标题
将痛苦温度计 (DT) 与患者健康问卷 (PHQ)-2 进行比较，以筛查新诊断的晚期癌症患者中可能的抑郁病例。
DOI：
10.1017/s1478951513000394
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发表时间：
2014
影响因子：
2.2
通讯作者：
McCorkle,Ruth
中科院分区：
文献类型：
--
作者：
Lazenby,Mark;Dixon,Jane;Bai,Mei;McCorkle,Ruth
抑郁筛查指南要求在癌症诊断时快速筛查情绪困扰。本研究的目的是检查的痛苦温度计（DT）的能力，以筛选在治疗晚期癌症的患者谁可能是depressed.MethodsUsing横断面数据收集的患者在30天内诊断为晚期癌症，本研究使用ROC分析来确定通过医生健康问卷（PHQ）-9;测试间的可靠性分析，比较DT与PHQ-2筛选可能的抑郁症的情况下，和多变量分析，以检查之间的关联DT情绪问题列表（EPL）项目与cases of depression. ResultsThe平均年龄的123例患者在研究中为59. 9（12. 9）岁。70例（56.9%）为女性。所有人都患有3期或4期癌症（40%胃肠道，19%妇科，20%头颈部，21%肺癌）。平均DT评分为4（2.7）/10;根据PHQ-9 ≥ 5测量，56例（43%）抑郁。筛选可能的抑郁症病例的最佳DT截止评分为≥ 2/10，灵敏度为.96，而PHQ-2 ≥ 2的灵敏度为.32。DT ≥ 2和PHQ-2与PHQ-9 ≥ 5的相关系数分别为0.4和-0.2。与抑郁症病例相关的EPL项目为抑郁（OR = 0.15，0.02 - 0.85）和悲伤（OR = 0.21，0.06 - 0.72）。EPL项目可与DT评分一起用于对患者进行分类以进行评价。
ObjectiveDistress screening guidelines call for rapid screening for emotional distress at the time of cancer diagnosis. The purpose of this study was to examine the distress thermometer's (DT) ability to screen in patients in treatment for advanced cancer who may be depressed.MethodsUsing cross-sectional data collected from patients within 30 days of diagnosis with advanced cancer, this study used ROC analysis to determine the optimal-cutoff point of the distress thermometer (DT) for screening for depression as measured by the physician health questionnaire (PHQ)-9; inter-test reliability analysis to compare the DT with the PHQ-2 for screening in possible cases of depression, and multivariate analysis to examine associations among the DT emotional problem list (EPL) items with cases of depression.ResultsThe average age of the 123 patients in the study was 59.9 (12.9) years. Seventy (56.9%) were female. All had Stage 3 or 4 cancers (40% gastrointestinal, 19% gynecologic, 20% head and neck, 21% lung). The mean DT score was 4 (2.7)/10; and 56 (43%) were depressed as measured by the PHQ-9 ≥5. The optimal DT cut-off score to screen in possible cases of depression was ≥2/10, with a sensitivity of .96, compared to a sensitivity of .32 of the PHQ-2 ≥2. Correlation coefficients for the DT ≥2 and the PHQ-2 with the PHQ-9 ≥5 were 0.4 and −0.2, respectively. EPL items associated with cases of depression were Depression (OR = 0.15, 0.02–0.85) and Sadness (OR = 0.21, 0.06–0.72).Significance of ResultsThe optimal DT threshold for identifying possible cases of depression at the time of diagnosis is ≥2; this threshold is more sensitive than the PHQ-2 ≥2. EPL items may be used with the DT score to triage patients for evaluation.