ONTOGENY OF THE SEROTONERGIC PROJECTION TO RAT NEOCORTEX - TRANSIENT EXPRESSION OF A DENSE INNERVATION TO PRIMARY SENSORY AREAS
ONTOGENY OF THE SEROTONERGIC PROJECTION TO RAT NEOCORTEX - TRANSIENT EXPRESSION OF A DENSE INNERVATION TO PRIMARY SENSORY AREAS
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DOI：
10.1073/pnas.84.12.4322
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发表时间：
1987-06-01
影响因子：
11.1
通讯作者：
SNYDER, SH
中科院分区：
文献类型：
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作者：
DAMATO, RJ;BLUE, ME;SNYDER, SH
用免疫组化5-羟色胺定位结合放射自显影研究大鼠大脑皮质的肾上腺素能神经支配的发育。新生大鼠大脑皮层各初级感觉区均有短暂的、密集的肾上腺素能神经支配。在躯体感觉皮层中，密集的多巴胺能神经支配与称为桶的特化细胞聚集体对齐。3周龄后致密斑片不明显，成年后新皮层的肾上腺素能神经支配变得更加均匀。这种早熟的新生儿肾上腺素能神经支配可能在皮层感觉区发挥过渡生理作用，或可能对皮层回路和丘脑皮层连接的发育产生营养影响。
The development of serotonergic innervation to rat cerebral cortex was characterized by immunohistochemical localization of serotonin combined with autoradiographic imaging of serotonin-uptake sites. In neonatal rat, a transient, dense, serotonergic innervation appears in all primary sensory areas of cortex. In somatosensory cortex, dense patches of serotonergic innervation are aligned with specialized cellular aggregates called barrels. The dense patches are not apparent after 3 weeks of age, and the serotonergic innervation becomes more uniform in adult neocortex. This precocious neonatal serotonergic innervation may play a transition physiologic role in sensory areas of cortex or may exert a trophic influence on the development of cortical circuitry and thalamocortical connections.