Quantitative measurements of second harmonic Doppler using ultrasound contrast agents
Quantitative measurements of second harmonic Doppler using ultrasound contrast agents
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DOI：
10.1016/s0301-5629(96)00146-9
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发表时间：
1996-01-01
影响因子：
2.9
通讯作者：
Levene, HB
中科院分区：
文献类型：
--
作者：
Chang, PH;Shung, KK;Levene, HB
使用两种超声造影剂Albunex（R）和FS 069进行二次谐波和一次谐波多普勒的定量测量。多普勒频移频谱的RMS幅度被测量为药剂浓度、频率和传输声压的函数。结果表明，对于所研究的给定批次造影剂，与Albunex相比，FS 069能够产生更高水平的一次谐波信号，尤其是二次谐波信号。在相同的实验条件下，FS 069的RMS多普勒振幅（RDA）在一次谐波时比Albunex高3.8 +/- 0.8 dB，在二次谐波时比Albunex高12.6 +/- 0.8 dB。二次谐波与一次谐波RDA之比，我们称之为R（2）/R（1），随着频率的增加，两种药物以7 dB/MHz的速率降低。在任何频率下，FS 069和Albunex之间的R（2）/R（1）值的差异约为4.5 dB，发现R（2）/R（1）作为两种试剂的传输声压的函数线性增加。使用Rayleigh-Plesset方程进行的模拟显示，R（2）/R（1）以5 dB/MHz的速率下降。实验结果与理论结果的比较表明，壳弹性参数可能是气泡平均直径的增函数。版权所有（C）1996世界医学和生物学超声联合会。
Quantitative measurements of second harmonic and first harmonic Doppler were carried out using two ultrasound contrast agents, Albunex(R) and FS069. The RMS amplitudes of the Doppler shift spectra were measured as a function of the concentration of the agents, frequency and transmitted acoustic pressure. The results showed that, for a given lot of contrast agent investigated, FS069 was able to produce higher levels of first and, especially, second harmonic signals compared to Albunex, Under the same experimental conditions, the RMS Doppler amplitude (RDA) of FS069 was 3.8 +/- 0.8 dB higher than Albunex at first harmonic and 12.6 +/- 0.8 dB higher at second harmonic. The ratio of the second harmonic to first harmonic RDA, which we called R(2)/R(1), decreases at a rate of 7 dB/MHz for both agents with increasing frequency. The difference in the value of R(2)/R(1) between FS069 and Albunex at any frequency was approximately 4.5 dB, R(2)/R(1) was found to increase linearly as a function of the transmitted acoustic pressure for both agents. Simulations using the Rayleigh-Plesset equation show a decrease of R(2)/R(1) at a rate of 5 dB/MHz. Comparison of experimental results with theory indicates that the shell elasticity parameter may be an increasing function of the mean diameter of the bubbles. Copyright (C) 1996 World Federation for Ultrasound in Medicine and Biology.