AN FGF RECEPTOR SIGNALING PATHWAY IS REQUIRED FOR THE NORMAL-CELL MIGRATIONS OF THE SEX MYOBLASTS IN C-ELEGANS HERMAPHRODITES
AN FGF RECEPTOR SIGNALING PATHWAY IS REQUIRED FOR THE NORMAL-CELL MIGRATIONS OF THE SEX MYOBLASTS IN C-ELEGANS HERMAPHRODITES
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DOI：
10.1016/0092-8674(95)90101-9
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发表时间：
1995-11-17
期刊：
影响因子：
64.5
通讯作者：
STERN, MJ
中科院分区：
文献类型：
--
作者：
DEVORE, DL;HORVITZ, HR;STERN, MJ
C.秀丽线虫雌雄同体经历向前定向的细胞迁移，这允许产卵肌肉的适当定位。这些迁移部分是由性腺细胞发出的信号控制的，该信号允许SM被吸引到性腺中心两侧的精确最终位置。egl-15的突变改变了性腺和SM之间相互作用的性质，导致SM的后移位。在这里，我们表明，egl-15编码成纤维细胞生长因子受体（FGFR）亚家族的受体酪氨酸激酶，在发展中具有多种作用。三个基因被鉴定为egl-15活性的遗传激活剂或介质。这些基因之一，sem-5，编码一个衔接分子，从各种受体酪氨酸激酶转导信号。与egl-15和sem-5一样，其他两个基因可能类似地在秀丽隐杆线虫中的FGFR信号通路中起作用。
The sex myoblasts (SMs) in C. elegans hermaphrodites undergo anteriorly directed cell migrations that allow for the proper localization of the egg-laying muscles. These migrations are controlled in part by a signal emanating from gonadal cells that allows the SMs to be attracted to their precise final positions flanking the center of the go nad. Mutations in egl-15 alter the nature of the interaction between the gonad and the SMs, resulting in the posterior displacement of the SMs. Here we show that egl-15 encodes a receptor tyrosine kinase of the fibroblast growth factor receptor (FGFR) subfamily with multiple roles in development. Three genes were identified that behave genetically as activators or mediators of egl-15 activity. One of these genes, sem-5, encodes an adaptor molecule that transduces signals from a variety of receptor tyrosine kinases. Like egl-15 and sem-5, the other two genes may similarly act in FGFR signaling pathways in C, elegans.