OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF CHOROIDAL NEOVASCULARIZATION IN FOUR INHERITED RETINAL DYSTROPHIES.
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF CHOROIDAL NEOVASCULARIZATION IN FOUR INHERITED RETINAL DYSTROPHIES.
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DOI：
10.1097/iae.0000000000001159
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Pennesi ME
中科院分区：
文献类型：
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作者：
Patel RC;Gao SS;Zhang M;Alabduljalil T;Al-Qahtani A;Weleber RG;Yang P;Jia Y;Huang D;Pennesi ME
展示光学相干断层扫描（OCT）血管造影（OCT- a）在遗传性视网膜营养不良（IRDs）合并脉络膜新生血管（CNV）中的临床应用。OCT- a和结构OCT使用70 kHz频谱域OCT系统，采用分谱幅度去相关血管造影算法。采用半自动图像处理软件对CNV进行分割和测量。4名参与者被纳入研究以下合并CNV的ird：脉络膜血症、efemp1相关视网膜病变、Best卵黄样营养不良和成人发病卵黄样营养不良。由于视网膜结构异常，荧光素血管造影很难解释，但提示CNV的存在。结构OCT显示视网膜下或rpe下纤维维管组织，OCT- a可见血流信号。CNV形态从活动性病变的密集毛细血管网络到无症状的大口径袢不等。基线CNV血管面积范围为0.07至0.98 mm2。玻璃体内贝伐单抗治疗后，脉络膜血症患者血管面积的CNV下降后反弹，而efemp1相关视网膜病变患者的CNV基本保持不变。OCT-A能够在视网膜结构扭曲的视网膜营养不良患者中进行CNV的形态学表征和量化，可以评估对治疗的反应，并有助于区分活动性和退行性病变。
To demonstrate the clinical utility of optical coherence tomography (OCT) angiography (OCT-A) in inherited retinal dystrophies (IRDs) complicated by choroidal neovascularization (CNV). OCT-A and structural OCT were performed using a 70 kHz spectral-domain OCT system employing the split-spectrum amplitude-decorrelation angiography algorithm. Semiautomated image processing software was used to segment and measure the CNV. Four participants were enrolled to study the following IRDs complicated by CNV: choroideremia, EFEMP1-related retinopathy, Best vitelliform dystrophy, and adult-onset vitelliform dystrophy. Interpretation of fluorescein angiography was difficult due to abnormal retinal architecture but suggested the presence of CNV. Structural OCT revealed subretinal or sub-RPE fibrovascular tissue, within which flow signal was observed on OCT-A. CNV morphology varied from dense capillary networks in active lesions to asymptomatic large caliber loops. Baseline CNV vessel areas ranged from 0.07 to 0.98 mm2. Following treatment with intravitreal bevacizumab, the CNV in choroideremia decreased in vessel area then rebounded, while the one in EFEMP1-related retinopathy remained largely unchanged. OCT-A enables the morphologic characterization and quantification of CNV in patients with retinal dystrophies despite distorted retinal architecture, can assess response to treatment, and may facilitate the differentiation between active and regressed lesions.