Fetal Electrocardiogram Extraction Using Dual-Path Source Separation of Single-Channel Non-Invasive Abdominal Recordings
Fetal Electrocardiogram Extraction Using Dual-Path Source Separation of Single-Channel Non-Invasive Abdominal Recordings
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DOI：
10.1109/tbme.2022.3189617
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发表时间：
2022-07
影响因子：
4.6
通讯作者：
Arash Shokouhmand;Negar Tavassolian
中科院分区：
文献类型：
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作者：
Arash Shokouhmand;Negar Tavassolian
目的：建立一种无创监测胎儿单道腹部心电图（FECG）的方法。研究方法：介绍了双路源分离（DPSS）架构，用于从腹部ECG记录中同时分离胎儿和母体ECG信号。DPSS最初使用生成双路径长短期记忆（DP-LSTM）网络对腹部ECG（AECG）记录进行降噪。然后采用具有一系列DP-LSTM块的起始模块沿着来提取与胎儿和母体分量相关联的掩蔽图。最后，通过AECG记录对这些掩蔽图进行加权以分离母体和胎儿ECG信号。该网络的性能进行了评估10例妊娠胎儿心电图合成数据库（FECGSYNDB），22例分娩和妊娠的腹部和直接胎儿心电图数据库（ADFECGDB），69例妊娠的非侵入性胎儿心电图挑战（NIFECGC）数据集A。结果：FECGSYNDB、ADFECGDB和NIFECGC中胎儿QRS波群检测的F1分数分别为99.03%、97.7%和95.3%。DPSS技术还评估了胎儿和母体集群的可分性。根据基于聚类的分析，平均纯度指数为0.9750，Jaccard指数为0.9705，Davies-Bouldin指数为0.7429，表明DPSS具有较高的源分离能力。结论：所实现的性能表明，DPSS能够实现准确的单通道FECG提取，并可以取代国家的最先进的源分离技术用于此目的。意义：这项研究标志着朝着无创胎儿心电图监测系统迈出了基础性的一步，有利于家庭产前护理。
Objective: The development of a method for non-invasive monitoring of fetal electrocardiogram (FECG) signals from single-channel abdominal recordings. Methods: The dual-path source separation (DPSS) architecture is introduced for the simultaneous separation of fetal and maternal ECG signals from abdominal ECG recordings. DPSS initially denoises abdominal ECG (AECG) recordings using a generative dual-path long short-term memory (DP-LSTM) network. An inception module along with a series of DP-LSTM blocks is then employed to extract the masking maps associated with fetal and maternal components. Finally, these masking maps are weighted by the AECG recording to separate maternal and fetal ECG signals. The performance of this network is evaluated on 10 pregnancies from the fetal ECG synthetic database (FECGSYNDB), 22 cases of labor and pregnancy from the abdominal and direct fetal ECG database (ADFECGDB), and 69 pregnancies from set A of non-invasive FECG challenge (NIFECGC) datasets. Results: F1-scores of 99.03%, 97.7%, and 95.3% are reported for the detection of fetal QRS complexes in FECGSYNDB, ADFECGDB, and NIFECGC respectively. DPSS technique is also evaluated in terms of separability of fetal and maternal clusters. According to the clustering-based analyses, the average purity index of 0.9750, Jaccard index of 0.9705, and Davies-Bouldin index of 0.7429 demonstrate the high source separation capability of DPSS. Conclusion: The achieved performance suggests that DPSS enables accurate single-channel FECG extraction, and can replace state-of-the-art source separation techniques for this purpose. Significance: This study signifies a fundamental step towards non-invasive fetal ECG monitoring systems, which favors at-home prenatal care.