An Evaluation of the Modified Diagnostic Criteria for DIC Established by the Japanese Society of Thrombosis and Hemostasis
An Evaluation of the Modified Diagnostic Criteria for DIC Established by the Japanese Society of Thrombosis and Hemostasis
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DOI：
10.1177/1076029616654263
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发表时间：
2017-09-01
影响因子：
2.9
通讯作者：
Katayama, Naoyuki
中科院分区：
文献类型：
--
作者：
Aota, Takumi;Wada, Hideo;Katayama, Naoyuki
目的：我们对108例疑似感染性DIC患者采用日本血栓与止血学会（JSTH）公布的弥散性血管内凝血（DIC）诊断标准进行了评价。材料与方法：患者诊断为DIC（n = 63）、DIC前期（n = 22）和非DIC（n = 45）。使用受试者操作特征分析评估DIC诊断标准的有效性。尽管诊断DIC的全凝血试验（GCT）评分曲线下面积较高，但诊断DIC和DIC前的曲线下面积较低，这表明加入抗凝血酶（AT）、可溶性纤维蛋白（SF）/凝血酶-AT复合物（达特），血小板计数（PLT）值降低是诊断DIC和DIC前期的必要条件。GCT评分结合AT、SF/达特、PLT降低值诊断DIC及DIC前期的临界值为5分。讨论和结论：采用GCT评分结合PLT、AT、达特/SF降低值的改良JSTH DIC诊断标准对DIC及DIC前期的诊断有一定的参考价值。
Objective: We evaluated the modified diagnostic criteria for disseminated intravascular coagulation (DIC), which was published by the Japanese Society of Thrombosis and Hemostasis (JSTH) in 108 patients with suspected infectious DIC.Material and methods: The diagnoses of the patients were as follows: DIC (n = 63), pre-DIC (n = 22), and non-DIC (n = 45). The efficacy of the diagnostic criteria for DIC was evaluated using a receiver-operating characteristic analysis.Results: Although the area under the curve for global coagulation test (GCT) scores in the diagnosis of DIC was high that for the diagnosis of DIC and pre-DIC was low, suggesting that the addition of antithrombin (AT), soluble fibrin (SF)/thrombin-AT complex (TAT), and reduced platelet count (PLT) values was required to diagnose DIC and pre-DIC. Using GCT score with the AT, SF/TAT, and reduced PLT values, the cutoff value of the DIC score for the diagnosis of DIC and pre-DIC was 5 points.Discussion and conclusion: The modified JSTH's diagnostic criteria for DIC, which used the GCT score and the reduced PLT, AT, and TAT/SF values, were useful for diagnosing DIC and pre-DIC.