Leptin, malnutrition, and immune response in rural Gambian children
Leptin, malnutrition, and immune response in rural Gambian children
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DOI：
10.1136/adc.87.3.192
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发表时间：
2002-09-01
影响因子：
5.2
通讯作者：
Prentice, AM
中科院分区：
文献类型：
--
作者：
Moore, SE;Morgan, G;Prentice, AM
背景：脂肪细胞源性激素瘦素（leptin）具有细胞因子样作用，可能介导饥饿对免疫功能的影响。先天性瘦素缺乏症（ob/ob）小鼠胸腺细胞减少，细胞免疫功能受损。在人类中，瘦素影响幼稚细胞和记忆细胞的体外分化，遗传性瘦素缺乏与不明确的感染易感性有关。目的：描述瘦素与儿童免疫功能的体内关系。方法：空腹血浆瘦素浓度、免疫功能（T和B细胞介导的疫苗反应和迟发型超敏反应），和粘膜功能（双重糖渗透试验和唾液sIgA浓度）进行了测量，在一个队列的472中度营养不良的农村冈比亚儿童。瘦素浓度与通过上臂中围或BMI年龄Z评分评估的体脂相关，与营养良好的欧洲标准相比非常低（男性1.8 v 11.1 ng/ml;女性2.4 v 13.8 ng/ml）。瘦素浓度和任何的免疫或粘膜functions.Conclusions的措施之间没有发现可检测的关系：数据证实，瘦素作为一个外围信号的能量限制，但不支持空腹血浆瘦素水平和免疫功能之间的关联在这个年龄段的儿童。
Background: The adipocyte derived hormone, leptin, has cytokine like function and may mediate the effects of starvation on immunity. Mice with congenital leptin deficiency (ob/ob) have small hypocellular thymuses and impaired cellular immunity. In humans leptin influences the differentiation of naive and memory cells in vitro, and genetic leptin deficiency has been associated with an ill defined susceptibility to infection.Aims: To describe the in vivo relation of leptin and immune function in children.Methods: Fasting plasma leptin concentrations, immune function (T and B cell mediated vaccine responses and delayed type hypersensitivity), and mucosal function (dual sugar permeability test and salivary sIgA concentrations) were measured in a cohort of 472 moderately undernourished rural Gambian children.Results: Leptin concentrations correlated with body fat assessed by mid upper arm circumference or BMI for age Z scores, and were very low compared to well nourished European norms (males 1.8 v 11.1 ng/ml; females 2.4 v 13.8 ng/ml). No detectable relations were found between leptin concentrations and any of the measures of immune or mucosal function.Conclusions: The data confirm that leptin acts as a peripheral signal of energy restriction, but do not support an association between fasting plasma leptin levels and immune function in children of this age.