Aging and Cone Dark Adaptation
Aging and Cone Dark Adaptation
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DOI：
10.1097/opx.0b013e318263c6b1
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发表时间：
2012-08-01
影响因子：
1.4
通讯作者：
Margrain, Tom H.
中科院分区：
文献类型：
--
作者：
Gaffney, Allannah J.;Binns, Alison M.;Margrain, Tom H.
目的.在暴露于强光下，漂白了大部分的色素，眼睛需要几分钟才能恢复敏感性。这种缓慢的过程，称为暗适应，在年龄相关性黄斑变性患者中受损，是这种疾病的重要候选生物标志物。本研究的目的是评估年龄对视锥细胞暗适应的影响。数据来自41名年龄在20至83岁之间的健康成年人。瞳孔放大，96%的视锥细胞色素被“漂白”，然后在黑暗中使用以中央凹为中心的4直径的消色差点连续监测阈值5分钟。对阈值恢复数据进行建模，并确定视锥恢复的时间常数（tau）、初始视锥阈值和最终视锥阈值。采用回归分析的方法确定年龄与视锥细胞暗适应参数之间的关系。锥头增加16.4秒/十年的生活，表明随着年龄的增长，逐渐放缓的黑暗适应。在整个成年期，锥体tau的这种变化是显著的（p < 0.0005）。年龄增长与视锥起始阈值（p = 0.84）和视锥终末阈值（p = 0.82）之间无显著相关性。我们的研究结果为健康成年人在完全漂白后与年龄相关的视锥细胞暗适应减缓提供了证据，这可能会导致从明亮到昏暗的明视光水平移动时的视觉困难。我们建议，考虑到年龄相关的显着下降，锥tau蛋白作为早期年龄相关性黄斑疾病的生物标志物的敏感性和特异性可以提高这一参数。（Optom维斯科学2012;89：1219-1224）
Purpose. Following exposure to a bright light that bleaches a significant portion of photopigment, the eyes take several minutes to regain sensitivity. This slow process, known as dark adaptation, is impaired in patients with age-related macular degeneration and is an important candidate biomarker for this disease. The aim of this study was to evaluate the effect of age on cone dark adaptation.Methods. Data were obtained from 41 healthy adults aged between 20 and 83 years. Pupils were dilated and 96% of cone photopigment was "bleached," before threshold was monitored continuously for 5 min in the dark, using a 4 diameter achromatic spot centered on the fovea. Threshold recovery data were modeled, and the time constant of cone recovery (tau), initial cone thresholds, and final cone thresholds were determined. Regression analysis was used to determine the relationship between age and cone dark adaptation parameters.Results. Cone tau increased by 16.4 s/decade of life, indicating a progressive slowing of dark adaptation with increasing age. This change in cone tau throughout adulthood was significant (p < 0.0005). There was no significant relationship between increasing age and initial cone threshold (p = 0.84) or final cone threshold (p = 0.82).Conclusions. Our results provide evidence for age-related slowing of cone dark adaptation after a full bleach in healthy adults, which is likely to contribute to visual difficulties when moving from bright to dim photopic light levels. We propose that the sensitivity and specificity of cone tau as a biomarker for early age-related macular disease could be improved by taking into account the significant age-related decline in this parameter. (Optom Vis Sci 2012;89:1219-1224)