Loss of breast cancer metastasis suppressor 1 protein expression predicts reduced disease-free survival in subsets of breast cancer patients
Loss of breast cancer metastasis suppressor 1 protein expression predicts reduced disease-free survival in subsets of breast cancer patients
复制标题
DOI：
10.1158/1078-0432.ccr-06-0635
复制
发表时间：
2006-11-15
影响因子：
11.5
通讯作者：
Casey, Graham
中科院分区：
文献类型：
--
作者：
Hicks, David G.;Yoder, Brian J.;Casey, Graham
目的：本研究旨在确定乳腺癌转移抑制因子1（BRMS 1）蛋白表达缺失对按雌激素受体（ER）、孕激素受体（PR）或HER2状态分层的乳腺癌患者的无病生存期的影响，并确定BRMS 1蛋白表达缺失是否与基因组拷贝数变化相关。对1995年1月1日至1996年12月31日期间在克利夫兰诊所接受手术的238名新诊断的乳腺癌患者的肿瘤进行了组织微阵列免疫组织化学分析，并与5年临床随访资料进行比较。基因组拷贝数的变化，确定了基于阵列的比较基因组杂交在47例乳腺癌从这个人口和比较BRMS1 staining.Results：BRMS1蛋白表达丢失的情况下，近25%。PR阴性（P = 0.006）或HER2阳性（P = 0.039）肿瘤患者，
Purpose: This study aims to determine the effect of loss of breast cancer metastasis suppressor 1 (BRMS1) protein expression on disease-free survival in breast cancer patients stratified by estrogen receptor (ER), progesterone receptor (PR), or HER2 status, and to determine whether loss of BRMS1 protein expression correlated with genomic copy number changes.Experimental Design: A tissue microarray immunohistochemical analysis was done on tumors of 238 newly diagnosed breast cancer patients who underwent surgery at the Cleveland Clinic between January 1, 1995 and December 31,1996, and a comparison was made with 5-year clinical follow-up data. Genomic copy number changes were determined by array-based comparative genomic hybridization in 47 breast cancer cases from this population and compared with BRMS1 staining.Results: BRMS1 protein expression was lost in nearly 25% of cases. Patients with tumors that were PR negative (P = 0.006) or HER2 positive (P = 0.039) and