Prolactin, growth hormone, and luteinizing hormone in the maintenance of testicular luteinizing hormone receptors.
Prolactin, growth hormone, and luteinizing hormone in the maintenance of testicular luteinizing hormone receptors.
复制标题
催乳素、生长激素和黄体生成素在维持睾丸黄体生成素受体中的作用。
作者：
W. Zipf;A. Payne;R. Kelch
为了进一步阐明垂体对睾丸功能的影响，我们研究了PRL、GH和LH单独或以各种组合对垂体切除成年大鼠睾丸LH受体浓度和睾酮合成响应LH（睾丸反应性）的维持的影响。垂体切除术后7天LH受体浓度降低80%，睾丸对LH的反应性降低70%。在术后6小时内开始PRL（75或150 μ g/天）或GH（75或150 μg/天）治疗，每天两次持续6天，可部分防止LH受体丢失。PRL（150 μg/d）和GH（150 μg/d）对LH受体浓度的影响是相加的。LH（5 μg/天）、PRL和GH的组合防止垂体切除术后LH受体的任何损失。LH对其受体的正效应发生在PRL的存在下。用5 μg LH加150 μg PRL治疗垂体切除大鼠，增强了单独PRL观察到的效果（1.31 pmol/睾丸vs. 1.68 pmol/睾丸）。
To elucidate further pituitary influence on testicular function, we studied the effect of PRL, GH, and LH alone or in various combinations on the maintenance of testicular LH receptor concentration and testosterone synthesis in response to LH (testicular responsiveness) in hypophysectomized adult rats. Hypophysectomy reduced LH receptor concentration by 80% and testicular responsiveness to LH by 70% 7 days after surgery. Treatment with PRL (75 or 150 μg/day) or with GH (75 or 150 μg/day) initiated within 6 h after surgery and continued twice daily for 6 days partially prevented the loss of LH receptors. The effect of PRL (150 μg/day) plus GH (150 μg/day) on LH receptor concentration was additive. The combination of LH (5 μg/day), PRL, and GH prevented any loss of LH receptors after hypophysectomy. A positive effect of LH on its receptor occurred in the presence of PRL. Treatment of hypophysectomized rats with 5 /μg LH plus 150 /μg PRL enhanced the effect observed with PRL alone (1.31 pmol/testis vs. 1.68 ...