Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila
Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila
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DOI：
10.1038/nn1957
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发表时间：
2007-09-01
影响因子：
25
通讯作者：
Newport, John W.
中科院分区：
文献类型：
--
作者：
Foltenyi, Krisztina;Greenspan, Ralph J.;Newport, John W.
哺乳动物下丘脑中的表皮生长因子受体（EGFR）信号传导在活动的昼夜调节中是重要的。我们已经研究了这条通路在调节果蝇睡眠中的作用。我们的研究结果表明，菱形（Rho）和星介导的EGFR和ERK信号的激活增加睡眠的剂量依赖性方式，和菱形（rho）在神经系统中的表达的阻滞减少睡眠。rho对睡眠的需求定位于大脑间部，这是苍蝇大脑的一部分，在发育和功能上类似于脊椎动物的下丘脑。这些结果表明，睡眠和EGFR信号调节可能是昆虫和哺乳动物的祖先。
Epidermal growth factor receptor ( EGFR) signaling in the mammalian hypothalamus is important in the circadian regulation of activity. We have examined the role of this pathway in the regulation of sleep in Drosophila melanogaster. Our results demonstrate that rhomboid ( Rho)- and Star-mediated activation of EGFR and ERK signaling increases sleep in a dose-dependent manner, and that blockade of rhomboid ( rho) expression in the nervous system decreases sleep. The requirement of rho for sleep localized to the pars intercerebralis, a part of the fly brain that is developmentally and functionally analogous to the hypothalamus in vertebrates. These results suggest that sleep and its regulation by EGFR signaling may be ancestral to insects and mammals.