Xenogeneic Decellularized Extracellular Matrix-based Biomaterials For Peripheral Nerve Repair and Regeneration.
Xenogeneic Decellularized Extracellular Matrix-based Biomaterials For Peripheral Nerve Repair and Regeneration.
复制标题
用于周围神经修复和再生的异种脱细胞细胞外基质生物材料
DOI：
10.2174/1570159x18666201111103815
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发表时间：
2021
影响因子：
5.3
通讯作者：
Ao, Qiang
中科院分区：
文献类型：
--
作者：
Li, Ting;Javed, Rabia;Ao, Qiang
关键词：
周围神经损伤可能导致受损或完全丧失功能的受影响的患者，和各种神经修复材料已被开发用于手术方法来修复it.Although自体或自体组织衍生的生物材料仍然是首选的治疗周围神经损伤，缺乏供体来源导致生物医学研究人员探索更多的其他生物材料。作为一种可靠的替代方法，异种脱细胞外基质（dECM）为基础的生物材料已被广泛用于外科神经修复。来源于动物供体的dECM是异种移植的有吸引力的和无限的来源。同时，作为一种日益流行的技术，脱细胞可以保留天然ECM中的多种生物活性成分，如多糖，蛋白质和生长因子。由此产生的基于dECM的生物材料保护组织的天然微环境，促进许旺细胞增殖和分化，并为神经再生提供线索。尽管基于dECM的生物材料作为治疗剂的潜力正在上升，但这种材料存在许多限制其使用的局限性。在此，本文综述了已被应用于创建dECM为基础的生物材料，神经ECM的主要成分，和异种dECM为基础的生物材料，通过应用程序作为一个水凝胶，包裹和引导导管在神经组织工程的最新进展的脱细胞技术。最后，阐述了异种dECM基生物材料存在的瓶颈和发展技术，可以消除，有助于未来的应用。
Peripheral nerve injury could lead to either impairment or a complete loss of function for affected patients, and a variety of nerve repair materials have been developed for surgical approaches to repair it. Although autologous or autologous tissue-derived biomaterials remain preferred treatment for peripheral nerve injury, the lack of donor sources has led biomedical researchers to explore more other biomaterials. As a reliable alternative, xenogeneic decellularized extracellular matrix (dECM)-based biomaterials have been widely employed for surgical nerve repair. The dECM derived from animal donors is an attractive and unlimited source for xenotransplantation. Meanwhile, as an increasingly popular technique, decellularization could retain a variety of bioactive components in native ECM, such as polysaccharides, proteins, and growth factors. The resulting dECM-based biomaterials preserve a tissue's native microenvironment, promote Schwann cells proliferation and differentiation, and provide cues for nerve regeneration. Although the potential of dECM-based biomaterials as a therapeutic agent is rising, there are many limitations of this material restricting its use. Herein, this review discusses the decellularization techniques that have been applied to create dECM-based biomaterials, the main components of nerve ECM, and the recent progress in the utilization of xenogeneic dECM-based biomaterials through applications as a hydrogel, wrap, and guidance conduit in nerve tissue engineering. In the end, the existing bottlenecks of xenogeneic dECM-based biomaterials and developing technologies that could be eliminated to be helpful for utilization in the future have been elaborated.