How to Untie a Protein Knot.
How to Untie a Protein Knot.
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DOI：
10.1016/j.str.2019.07.008
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发表时间：
2019-08
期刊：
影响因子：
5.7
通讯作者：
Sitao Yin;Brittiny Dhital;Ya-Ming Hou
中科院分区：
文献类型：
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作者：
Sitao Yin;Brittiny Dhital;Ya-Ming Hou
穿过拓扑结的蛋白质主链的起源仍然难以捉摸。为了了解蛋白质结的进化起源，在本期的 StructureKo 等人中。 (2019) 使用循环排列来解开打结的蛋白质。他们表明，结构域交换的二聚体释放结和相关的底物结合的高能态。
The origin of protein backbone threading through a topological knot remains elusive. To understand the evolutionary origin of protein knots, in this issue ofStructureKo et al. (2019) used circular permutation to untie a knotted protein. They showed that a domain-swapped dimer releases the knot and the associated high-energy state for substrate binding.