Subversion of the chemotherapy-induced anticancer immune response by the ecto-ATPase CD39.
Subversion of the chemotherapy-induced anticancer immune response by the ecto-ATPase CD39.
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DOI:
10.4161/onci.19070
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发表时间:
2012-05-01
期刊:
影响因子:
7.2
通讯作者:
Kroemer G
中科院分区:
文献类型:
--
作者:
Michaud M;Sukkurwala AQ;Martins I;Shen S;Zitvogel L;Kroemer G
The efficacy of antineoplastic chemotherapies with anthracyclines or oxaliplatin relies on the induction of immunogenic cell death, thus provoking an anticancer immune response. Recently, we observed that overexpression of CD39, an ATP-degrading enzyme expressed on the cell surface, abolishes the immunogenicity of cell death, thus rendering cancers resistant against chemotherapy.
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