Synaptogenesis and dendritic growth in the cortex opposite unilateral sensorimotor cortex damage in adult rats: A quantitative electron microscopic examination
Synaptogenesis and dendritic growth in the cortex opposite unilateral sensorimotor cortex damage in adult rats: A quantitative electron microscopic examination
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DOI：
10.1016/0006-8993(96)00792-5
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发表时间：
1996-09-09
期刊：
影响因子：
2.9
通讯作者：
Greenough, WT
中科院分区：
文献类型：
--
作者：
Jones, TA;Kleim, JA;Greenough, WT
与假手术组相比，损毁成年大鼠一侧感觉运动皮质前肢区后，对侧运动皮质V层内每个神经元的突触数目和突起的体积和膜表面积均呈时间依赖性增加。根据先前发现的与树突状分支增加的行为关系，这些变化可能与病变引起的非受损(病变同侧)前肢的代偿性使用变化有关。
Unilateral lesions of the forelimb area of the sensorimotor cortex in adult rats resulted in time-dependent increases in the number of synapses per neuron and the volume and membrane surface area oi dendritic processes per neuron within layer V of the contralateral motor cortex in comparison to sham-operated rats. Based on previous findings of a behavioral relationship with increased dendritic arborization, these changes may be related to lesion-induced compensatory changes in the use of the non-impaired (ipsilateral to the lesion) forelimb.