MODULATION OF EARLY SENSORY PROCESSING IN HUMAN AUDITORY-CORTEX DURING AUDITORY SELECTIVE ATTENTION
MODULATION OF EARLY SENSORY PROCESSING IN HUMAN AUDITORY-CORTEX DURING AUDITORY SELECTIVE ATTENTION
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DOI：
10.1073/pnas.90.18.8722
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发表时间：
1993-09-15
影响因子：
11.1
通讯作者：
BLOOM, FE
中科院分区：
文献类型：
--
作者：
WOLDORFF, MG;GALLEN, CC;BLOOM, FE
当人类受试者选择性地听一只耳朵中快速呈现的音调序列，而忽略另一只耳朵中不同音高的音调时，记录了他们的神经磁场。在20-50毫秒和80-130毫秒刺激后的潜伏期范围内，在参加的耳朵比无人值守的音调诱发更大的磁脑反应。源定位技术结合磁共振成像将这些早期注意力敏感的大脑反应的神经发生器放置在颞上平面的听觉皮层中。这些数据表明，集中的听觉注意力在人类可以选择性地调节听觉皮层的感觉处理开始早在20毫秒poststimulation，从而提供了强有力的证据，听觉注意力的“早期选择”的机制，可以调节听觉输入的皮层分析的初始阶段或之前。
Neuromagnetic fields were recorded from human subjects as they listened selectively to sequences of rapidly presented tones in one ear while ignoring tones of a different pitch in the opposite ear. Tones in the attended ear evoked larger magnetic brain responses than did unattended tones in the latency ranges 20-50 msec and 80-130 msec poststimulus. Source localization techniques in conjunction with magnetic resonance imaging placed the neural generators of these early attention-sensitive brain responses in auditory cortex on the supratemporal plane. These data demonstrate that focused auditory attention in humans can selectively modulate sensory processing in auditory cortex beginning as early as 20 msec poststimulus, thereby providing strong evidence for an ''early selection'' mechanism of auditory attention that can regulate auditory input at or before the initial stages of cortical analysis.