Plasminogen activators potentiate thrombin-induced brain injury
Plasminogen activators potentiate thrombin-induced brain injury
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DOI：
10.1161/01.str.29.6.1202
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发表时间：
1998-06-01
期刊：
影响因子：
8.3
通讯作者：
Hoff, JT
中科院分区：
文献类型：
--
作者：
Figueroa, BE;Keep, RF;Hoff, JT
背景和目的--有证据表明脑出血(ICH)后的脑水肿是质量效应和凝血酶等凝块衍生底物造成的神经毒性损伤相结合的结果。溶栓剂可以竞争大脑内源性的凝血酶抑制物。本研究观察了溶栓剂、组织型纤溶酶原激活剂(TPA)和尿激酶剂(UPA)单独及与凝血酶联合脑内灌注的效果。方法：成年雄性大鼠右侧基底节立体定向注入不同浓度的L溶液。结果：无论剂量大小，单独输注tPA(2微克)和uPA(2000和5000犁单位)均不能引起明显的组织水肿，而当溶栓剂与凝血酶(1或5U)同时输注时，脑水、钠和钾含量均明显增强(P<0.05)。
Background and Purpose-Evidence suggests that cerebral edema following intracerebral hemorrhage (ICH) results from a mass effect in combination with neurotoxic injury from clot-derived substrates such as thrombin. Thrombolytics can compete for thrombin inhibitors endogenous to the brain. This study examines the effect of intracerebral infusion of thrombolytics, tissue plasminogen activator (tPA), and urokinase (uPA), individually and in combination with thrombin.Methods-Various 100 mu L solutions were stereotactically infused into the right basal ganglia of adult male rats. Animals were euthanized 24 hours later, and brain sections were taken for measurement of water, sodium, and potassium content.Results-Regardless of dose, when infused independently tPA (2 mu g) and uPA (2000 and 5000 Plough units) failed to produce any significant tissue edema compared with vehicle control tissues, However, when either thrombolytic was infused concomitantly with thrombin (1 or 5 U), brain water, sodium, and potassium content all demonstrated a potentiation of thrombin-induced brain injury (P