Myelomastocytic Leukemia With t(8;21) in a 3-year-old Child
Myelomastocytic Leukemia With t(8;21) in a 3-year-old Child
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3 岁儿童 t(8;21) 骨髓肥大细胞白血病
DOI：
10.1097/mph.0b013e3182329b80
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
H. Meyerson
中科院分区：
文献类型：
--
作者：
Stefanos Intzes;S. Wiersma;H. Meyerson
在这里，我们报告一个3岁的男孩与骨髓肥大细胞白血病。患者出现疲劳和右眼突出。骨髓检查显示急性髓性白血病伴t（8;21）和8号染色体三体。诱导治疗使骨髓成粒细胞显着减少，出现13%的非典型肥大细胞。这些细胞随后在诊断性骨髓中被鉴定为符合骨髓肥大细胞白血病。他的临床病程以难以根除白血病过程而著称，与全身性肥大细胞增多症伴相关血液学非肥大细胞谱系疾病的成人相似。据我们所知，这是报告中最年轻的人。肥大细胞系参与急性髓系白血病的影响进行了审查。
Here we report a 3-year-old boy with myelomastocytic leukemia. The patient presented with fatigue and right eye proptosis. Bone marrow revealed acute myeloid leukemia with t(8;21) and trisomy 8. Induction therapy produced marked reduction in marrow myeloblasts with the emergence of 13% atypical mast cells. These cells were subsequently identified in retrospect in the diagnostic marrow consistent with myelomastocytic leukemia. His clinical course was notable for the difficulty in the eradication of the leukemic process and resembled that of adults with systemic mastocytosis with associated hematologic non-mast cell lineage disease. To the best of our knowledge, this is the youngest individual reported. The implications of mast cell lineage involvement in acute myeloid leukemia are reviewed.