Carcinoid Tumors of the Gastrointestinal Tract: Trends in Incidence in England Since 1971
Carcinoid Tumors of the Gastrointestinal Tract: Trends in Incidence in England Since 1971
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DOI：
10.1038/ajg.2010.341
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发表时间：
2010-12-01
影响因子：
9.8
通讯作者：
Coleman, Michel P.
中科院分区：
文献类型：
--
作者：
Ellis, Libby;Shale, Matthew J.;Coleman, Michel P.
结论：胃肠道神经内分泌肿瘤（GI-NETs）的流行病学知之甚少。最近的分析表明这种肿瘤的发病率和分布发生了变化，但通常使用的数据集包含少量患者。我们的目的是确定在流行病学的GI-NET在英格兰超过36 years periods.METHODS的趋势：我们分析了从全国人口为基础的癌症登记处，其中包括人口超过50万，在1971年至2006年期间的数据。男性的总发病率从0.27（每年每10万人）增加到1.32，女性从0.35增加到1.33。最近一个时期分析的肿瘤解剖分布为胃12%，小肠29%，阑尾38%，结肠13%，直肠8%。阑尾的发病率绝对增幅最大（男性从0.03增至0.41;女性从0.05增至0.59）。相对增加最多的是胃NET，男性增加2，325%，女性增加4，746%。总体而言，48%的GI-NET发生在男性中。性别特异性的发病率为胃，结肠，直肠NET是相似的，而apoptoeal病变更常见于女性，和小肠肿瘤在man.CONCLUSIONS：大的GI-NET的发病率增加，观察，沿着与解剖分布的变化。这种变化可能部分反映了分类的变化或通过增加使用内窥镜和成像技术而改进的检测。鉴于这些变化的幅度，特别是胃肿瘤，进一步的研究，以检查这些变化的潜在病因是迫切需要的。
OBJECTIVES: The epidemiology of gastrointestinal neuroendocrine tumors (GI-NETs) is poorly understood. Recent analyses have suggested changes in the incidence and distribution of such tumors, but have generally used data sets containing small patient numbers. We aimed to define trends in the epidemiology of GI-NETs in England over a 36-year period.METHODS: We analyzed data from the national population-based cancer registry, which covers a population in excess of 50 million, over the period 1971-2006.RESULTS: In all, 10,324 cases of GI-NETs were identified. The overall incidence increased from 0.27 (per 100,000 per year) to 1.32 for men and from 0.35 to 1.33 for women. The anatomic distribution of tumors in the latest period analyzed was stomach 12%, small intestine 29%, appendix 38%, colon 13%, and rectum 8%. The largest absolute increase in incidence was seen in the appendix (from 0.03 to 0.41 in men; from 0.05 to 0.59 in women). The greatest relative increase was in gastric NETs, increasing 2,325% in men, and 4,746% in women. Overall, 48% of GI-NETs occurred in men. Sex-specific incidence rates for gastric, colonic, and rectal NETs are similar, whereas appendiceal lesions were more common in females, and small intestinal tumors in men.CONCLUSIONS: Large increases in the incidence of GI-NETs were observed, along with changes in anatomical distribution. Such changes may partly reflect changes in classification or improved detection through the increased use of endoscopy and imaging techniques. In view of the magnitude of these changes, particularly for gastric tumors, further studies to examine the underlying etiology of these changes are urgently indicated.