Two Pairs of Neurons in the Central Brain Control Drosophila Innate Light Preference
Two Pairs of Neurons in the Central Brain Control Drosophila Innate Light Preference
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中枢大脑中的两对神经元控制果蝇先天的光偏好
DOI：
10.1126/science.1195993
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发表时间：
2010-10-22
期刊：
影响因子：
56.9
通讯作者：
Liu, Li
中科院分区：
文献类型：
--
作者：
Gong, Zhefeng;Liu, Jiangqu;Liu, Li
对光线或黑暗条件的适当偏好对动物的生存至关重要。在某些动物中，天生的光偏好并不是一成不变的，包括果蝇（Drosophila melanogaster），它在幼虫阶段喜欢黑暗，但在成年期更喜欢光线。为了阐明光偏好的神经回路，我们研究了参与幼虫趋光行为的神经元，通过调节神经元功能。调节活动的两对同构的神经元在中枢神经系统之间切换幼虫的光偏好之间的嗜光和嗜光。这些神经元被发现是直接下游的pdf表达侧神经元，这是受幼虫的光感受器。我们的研究结果揭示了一种神经机制，可以根据生物需要调整动物对环境刺激的反应策略。
Appropriate preferences for light or dark conditions can be crucial for an animal's survival. Innate light preferences are not static in some animals, including the fruit fly Drosophila melanogaster, which prefers darkness in the feeding larval stage but prefers light in adulthood. To elucidate the neural circuit underlying light preference, we examined the neurons involved in larval phototactic behavior by regulating neuronal functions. Modulating activity of two pairs of isomorphic neurons in the central brain switched the larval light preference between photophobic and photophilic. These neurons were found to be immediately downstream of pdf-expressing lateral neurons, which are innervated by larval photoreceptors. Our results revealed a neural mechanism that could enable the adjustment of animals' response strategies to environmental stimuli according to biological needs.