Current concepts in periodontal bioengineering.
Current concepts in periodontal bioengineering.
复制标题
DOI：
10.1111/j.1601-6343.2005.00352.x
复制
发表时间：
2005-11
影响因子：
3.1
通讯作者：
M. Taba;Q. Jin;J. Sugai;W. Giannobile
中科院分区：
文献类型：
--
作者：
M. Taba;Q. Jin;J. Sugai;W. Giannobile
修复因牙周和种植体周围组织破坏而导致的牙槽骨支持骨缺损是重建治疗的主要目标。口腔和颅面组织工程已经取得了有限的成功，通过使用各种方法，如细胞闭塞屏障膜，骨替代物和自体块移植技术。生长因子等信号分子已被用于修复因牙周病或创伤而失去的牙齿支撑。本文将从材料科学、生长因子生物学和细胞/基因治疗等方面综述牙周治疗的新进展。几种不同的聚合物递送系统，有助于将蛋白质、基因和细胞靶向牙周和种植体周围的缺陷，将被重点介绍。临床前和临床试验的结果将通过局部应用骨形态发生蛋白(BMP-2和BMP-7)和血小板衍生生长因子-BB(PDGF)来进行牙周和种植体周围的再生。本文综述了通过编码促进和抑制生长的分子(PDGF、BMP、Noggin等)的基因治疗载体，利用体内和体外基因治疗策略来再生牙周结构的最新研究成果，包括骨、牙周膜和牙骨质。
Repair of tooth supporting alveolar bone defects caused by periodontal and peri-implant tissue destruction is a major goal of reconstructive therapy. Oral and craniofacial tissue engineering has been achieved with limited success by the utilization of a variety of approaches such as cell-occlusive barrier membranes, bone substitutes and autogenous block grafting techniques. Signaling molecules such as growth factors have been used to restore lost tooth support because of damage by periodontal disease or trauma. This paper will review emerging periodontal therapies in the areas of materials science, growth factor biology and cell/gene therapy. Several different polymer delivery systems that aid in the targeting of proteins, genes and cells to periodontal and peri-implant defects will be highlighted. Results from preclinical and clinical trials will be reviewed using the topical application of bone morphogenetic proteins (BMP-2 and BMP-7) and platelet-derived growth factor-BB (PDGF) for periodontal and peri-implant regeneration. The paper concludes with recent research on the use of ex vivo and in vivo gene delivery strategies via gene therapy vectors encoding growth promoting and inhibiting molecules (PDGF, BMP, noggin and others) to regenerate periodontal structures including bone, periodontal ligament and cementum.